古代人类肠道中类似四环素的抵抗组

Q1 Medicine Human Microbiome Journal Pub Date : 2018-12-01 DOI:10.1016/j.humic.2018.07.001
Tasha M. Santiago-Rodriguez , Gino Fornaciari , Stefania Luciani , Gary A. Toranzos , Isolina Marota , Valentina Giuffra , Naseer Sangwan , Raul J. Cano
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引用次数: 4

摘要

四环素是在70 年前发现的,它们的使用导致了四环素耐药微生物的出现;然而,据推测,四环素耐药性可能起源于环境,并将决定因素转移到人类肠道微生物群。古代微生物群为探索四环素耐药决定因素从环境向人类的传播提供了机会。本研究利用高通量测序技术对3具前印加/印加木乃伊(10 - 15世纪)和5具意大利贵族木乃伊(15 - 16世纪)的四环素样抗性组进行了鉴定。序列显示低同源性,以今天的决定因素。结果可能有助于了解四环素耐药性的演变。
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Tetracycline-like resistome of ancient human guts

Tetracyclines were discovered over 70 years ago and their use resulted in the emergence of tetracycline-resistance microorganisms; however, it has been hypothesized that tetracycline-resistance may have originated in the environment, and that determinants were transferred to the human gut microbiota. Ancient microbiomes represent an opportunity to explore the transmission of tetracycline-resistance determinants from the environment to humans. In the present study, tetracycline-like resistomes of three pre-Inca/Inca (10–15th centuries), and five Italian nobility (15–16th centuries) mummies were characterized using high-throughput sequencing. Sequences exhibited low homology to present-day determinants. Results may aid in the understanding of the evolution of tetracycline-resistance.

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Human Microbiome Journal
Human Microbiome Journal Medicine-Infectious Diseases
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期刊介绍: The innumerable microbes living in and on our bodies are known to affect human wellbeing, but our knowledge of their role is still at the very early stages of understanding. Human Microbiome is a new open access journal dedicated to research on the impact of the microbiome on human health and disease. The journal will publish original research, reviews, comments, human microbe descriptions and genome, and letters. Topics covered will include: the repertoire of human-associated microbes, therapeutic intervention, pathophysiology, experimental models, physiological, geographical, and pathological changes, and technical reports; genomic, metabolomic, transcriptomic, and culturomic approaches are welcome.
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