酮体在癫痫生酮饮食治疗中的研究进展

Q4 Medicine 中华实用儿科临床杂志 Pub Date : 2020-01-05 DOI:10.3760/CMA.J.ISSN.2095-428X.2020.01.021

Xiaoying Qiao, J. Liao

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引用次数: 0

摘要

生酮饮食疗法（KDT）是一种高脂肪、低碳水化合物、适当蛋白质和其他营养素的配方饮食，主要用于治疗儿童顽固性癫痫。KDT过程中身体的主要代谢变化是产生大量酮体，酮体不仅可以提供能量，而且在抑制异常兴奋信号在大脑中的传递方面发挥着重要作用。然而，酮体在KDT中的抗癫痫机制仍然不太清楚。一些临床研究发现，血酮水平与控制癫痫的效果不一致。本文综述了酮体在生酮饮食治疗中的合成、监测、有效浓度范围及其与疗效关系的最新研究进展，以期为临床生酮饮食提供参考。关键词：酮体；生酮饮食疗法；癫痫

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Research progress of ketone bodies in ketogenic diet therapy of epilepsy

Ketogenic dietary therapy (KDT) is a kind of formulated diet with high fat, low carbohydrates, and appropriate protein and other nutrients, which is mainly used for the treatment of intractable epilepsy in children.The main metabolic change in the body during KDT is the production of a large number of ketone bodies which can not only provide energy, but also plays an important role in inhibiting the transmission of abnormal excitatory signals in the brain.However, the anti-epileptic mechanism of ketone bodies in KDT is still not very clear.Some clinical studies have found that the level of blood ketone is inconsistent with the effect of epilepsy control.The latest progress of research on the synthesis, monitoring, effective concentration range and the relationship with efficacy of ketone bodies in ketogenic diet therapy are reviewed in this article, in order to provide reference blood ketone range in clinical ketogenic diet. Key words: Ketone bodies; Ketogenic dietary therapy; Epilepsy

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来源期刊

中华实用儿科临床杂志 Medicine-Pediatrics, Perinatology and Child Health

CiteScore

0.60

自引率

0.00%

发文量

14243

期刊介绍： Chinese Journal of Applied Clinical Pediatrics ( semi-monthly ) is a core journal of paediatrics under the supervision of China Association for Science and Technology, sponsored by Chinese Medical Association and undertaken by Xinxiang Medical College. Founded in 1986, it is openly circulated both at home and abroad. The journal has several columns, such as Expert Forum, Experimental Research and Paediatric Surgery, which are mainly for paediatric medical workers and medical researchers in hospitals. Its purpose is to reflect the new theories and technologies in paediatric medicine and scientific research at home and abroad, and to promote academic exchanges. Chinese Journal of Applied Clinical Pediatrics is a source journal of China Science Citation Database (CSCD), a core journal of Peking University, a source journal of Chinese science and technology paper statistics (China Science and Technology Core Journals), a core academic journal of RCCSE, a high-quality scientific and technical journal of China, a high-quality scientific and technical journal of China Association for Science and Technology, and a high-quality scientific and technical journal of China Biomedical Science and Technology Association. We have been published in China Biomedical Literature Database (SinoMed), China Knowledge Network, Wanfang Data Knowledge Service Platform, China Academic Journal Abstracts, Scopus Database, Chemical Abstracts (USA), Japan Science and Technology Agency (JSTA) Database, Copernicus Abstracts (Poland), Abstracts of the Centre for Agricultural and Biological Sciences (CABS) of the United Kingdom, Cambridge Scientific Abstracts ProQuest Database, WHO Medical Journal of the Western Pacific Region (WMPR), and WHO Medical Journal of the Western Pacific Region (WMPR) of the United States. We have been included in dozens of authoritative databases at home and abroad, such as WHO Western Pacific Region Index of Medicine (WPRIM), Ullrich's Guide to Periodicals, and so on.