Jiandong Liu, Tianle Cang, Congli Jiang, Kelei Li, Siyuan Liu, Haixin Wang, Meirong Wang, Yan Chen, Yan Shao, Jiankai Liu
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CpG 684: an effective adjuvant for the inactivated COVID-19 vaccine in mice.
Aim: This study used CpG 684 as adjuvant of inactivated COVID-19 vaccine to detect a humoral and cellular immune response in mice.
Materials & methods: We used 10 and 20 µg CpG 684 as adjuvants of an inactivated COVID-19 vaccine to immunize mice. IgG, IgG1, IgG2a, IgG2b and IgM binding antibodies were detected in serum by ELISA. The IFN-γ cytokine was detected by ELISPOT.
Results: CpG 684 improved spike-specific IgG and IgM subtype binding antibodies and increased the neutralizing antibody titer against prototype, Delta and Beta strains. CpG 684 also improved cellular immune response.
Conclusion: CpG 684 is an effective adjuvant for inactivated COVID-19 vaccine.
期刊介绍：
Future Virology is a peer-reviewed journal that delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this ever-expanding area of research. It is an interdisciplinary forum for all scientists working in the field today.
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