原发性双侧卵巢淋巴瘤:一例罕见病例报告

Salwa Bano, V. Ramaswamy, C. Chandrashekar
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引用次数: 0

摘要

原发性卵巢淋巴瘤占所有卵巢恶性肿瘤的0.5%。我们报告一个这样的情况下,在一个中年妇女谁提出了一个双侧卵巢肿瘤。双侧卵巢切除术和输卵管切除术被送去做冷冻切片分析,发现一个圆形细胞肿瘤。最终组织病理学显示一个有丝分裂活跃的小圆形蓝色细胞瘤,呈弥漫性片状和弦状排列,呈明显的星空状。进行广泛的免疫组化(IHC)检测。组织病理学和免疫组化未将肿瘤分类为弥漫性大B细胞淋巴瘤或伯基特淋巴瘤,最终诊断为高级别B细胞淋巴瘤(HGBL)。本病例因其罕见而呈现,并讨论免疫组化将淋巴瘤亚分类为HGBL的挑战。虽然罕见,但在处理双侧卵巢肿瘤时应注意原发性卵巢非霍奇金淋巴瘤的可能性,及时准确的诊断可以节省不必要的手术,改善预后。
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Primary Bilateral Ovarian Lymphoma: A Rare Case Report
Primary ovarian lymphomas constitute 0.5% of all ovarian malignancies. We report one such case in a middle-aged woman who presented with a bilateral ovarian tumor. Bilateral oophorectomy with salpingectomy was sent for frozen section analysis that revealed a round cell tumor. Final histopathology showed a mitotically active small round blue cell tumor arranged in diffuse sheets and chords with an evident starry-sky pattern. Extensive immunohistochemistry (IHC) panel was performed. Histopathology along with IHC did not classify the tumor into diffuse-large-B cell-lymphoma or Burkitt lymphoma and a final diagnosis of high-grade B cell lymphoma (HGBL) was made. This case is presented for its rarity and to discuss the challenges on IHC to subclassify a lymphoma as HGBL. Although rare, the possibility of primary ovarian non-Hodgkin lymphoma should be kept in mind when dealing with bilateral ovarian tumors as a timely and accurate diagnosis can save unnecessary surgeries and improve outcome.
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审稿时长
22 weeks
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