多功能化单壁碳纳米管作为递送载体:促进阿霉素的靶向吸收和抗肿瘤效果

IF 2.3 4区 化学 Q2 Agricultural and Biological Sciences Journal of Inclusion Phenomena and Macrocyclic Chemistry Pub Date : 2022-09-22 DOI:10.1007/s10847-022-01163-0
Shuoye Yang, Jiaxin Liu, Yahong Ping, Zhenwei Wang, Jiaying Zhang, Lu Zhang, Lan Cui, Yongmei Xiao, Lingbo Qu
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引用次数: 1

摘要

单壁碳纳米管(SWCNTs)作为一种碳基纳米材料,由于其突出的性能被广泛认为是潜在的有效的药物递送载体。然而,它们的生物医学应用,特别是在给药领域的应用受到一些固有缺陷的严重限制。在本研究中,SWCNTs材料分别通过共价和非共价方法实现功能化。简而言之,首先用强氧化酸(H2SO4/HNO3)纯化原始SWCNTs,然后用不同的改性剂(包括聚乙二醇(PEG)、聚乙烯亚胺(PEI)、叶酸(FA)和壳聚糖(CS))依次附着羧基化的CNTs。然后对各种纳米载体进行了系统表征和比较评价。结果表明,所有CNTs样品均具有较高的载药效率、良好的生物相容性和药物释放反应性,可作为药物递送载体。与其他CNTs相比,多功能化CNTs (CNTs- ppfc)表现出更优异的性能,如在低pH条件下快速释放药物,更高的细胞内化效率,以及对MCF-7细胞的抗肿瘤活性增强。这些优势应归因于它们更好的分散状态和与肿瘤细胞相对较高的亲和力,这有利于更有效的选择性细胞摄取和随后的药物积累。此外,进一步的药理学机制分析也表明,CNTs-PPFC/DOX可以最有效地诱导MCF-7细胞凋亡,通过触发ROS过量产生和影响细胞周期分布。综上所述,多功能化碳纳米管- ppfc是一种很有前途的纳米载体,该研究结果将有助于合理设计新型抗癌药物递送载体。
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Multi-functionalized single-walled carbon nanotubes as delivery carriers: promote the targeting uptake and antitumor efficacy of doxorubicin

As one of carbon-based nanomaterials, single-walled carbon nanotubes (SWCNTs) are widely regarded as potentially potent drug delivery carriers on account of their prominent properties. Nevertheless, their biomedical application, particularly in the drug delivery field has been seriously restricted by some inherent defects. In this study, SWCNTs materials were functionalized by covalent and non-covalent approaches, respectively. In short, the pristine SWCNTs were first purified with strong oxidizing acids (H2SO4/HNO3), and the resulting carboxylated ones (CNTs) were attached sequentially by different modification agents, including polyethylene glycol (PEG), polyethyleneimine (PEI), folic acid (FA) and chitosan (CS). Various nanocarriers were then systematically characterized and comparatively evaluated. The results illustrated that all CNTs samples could act as drug delivery carriers since they had high drug loading efficiency, good biocompatibility and responsive drug release. In comparison with other CNTs, multi-functionalized ones (CNTs-PPFC) exhibited more excellent performance, such as rapid drug release at low pH condition, higher cell internalization efficiency, and enhanced antitumor activity toward MCF-7 cells. These advantages should be attributed to their better dispersion state and comparably higher affinity with tumor cells, which favor the more efficient selective cellular uptake and subsequent drug accumulation. Moreover, further pharmacological mechanism analysis also revealed that CNTs-PPFC/DOX could induce the apoptosis of MCF-7 cells most effectively, by triggering ROS overproduction and affecting cell cycle distribution. In conclusion, the multi-functionalized CNTs-PPFC can be utilized as promising nanocarriers, and the findings will contribute to the rational design of novel delivery vehicles for anticancer drugs.

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来源期刊
CiteScore
3.30
自引率
8.70%
发文量
0
审稿时长
3-8 weeks
期刊介绍: The Journal of Inclusion Phenomena and Macrocyclic Chemistry is the premier interdisciplinary publication reporting on original research into all aspects of host-guest systems. Examples of specific areas of interest are: the preparation and characterization of new hosts and new host-guest systems, especially those involving macrocyclic ligands; crystallographic, spectroscopic, thermodynamic and theoretical studies; applications in chromatography and inclusion polymerization; enzyme modelling; molecular recognition and catalysis by inclusion compounds; intercalates in biological and non-biological systems, cyclodextrin complexes and their applications in the agriculture, flavoring, food and pharmaceutical industries; synthesis, characterization and applications of zeolites. The journal publishes primarily reports of original research and preliminary communications, provided the latter represent a significant advance in the understanding of inclusion science. Critical reviews dealing with recent advances in the field are a periodic feature of the journal.
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