(Methyl-4-hydroxy-2) - 2-hydroxypropan-2-yl 6-methyl-2 3-dihydrobenzofuran-5-carboxylate

IF 0.6 Q4 CHEMISTRY, ORGANIC Molbank Pub Date : 2023-07-19 DOI:10.3390/m1697
Rishi Vachaspathy Astakala, Gagan Preet, R. Ebel, M. Jaspars
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引用次数: 0

摘要

微生物是具有药理活性的化合物的重要来源,既是合成的先导又是合成的支架。通常,有趣的化学反应是通过探索新的生物群系而发现的,智利阿塔卡马沙漠就是一个典型的例子。本文描述了一种新的化合物的分离和结构表征,使用HR-LCMS和1D和2D NMR,属于化合物家族称为radstrictin。这种化合物是从一种真菌中分离出来的,而这种真菌本身是从阿塔卡马沙漠的土壤样本中分离出来的。该化合物对与牛乳腺炎相关的致病菌株进行了测试,但发现缺乏抗菌活性。
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Methyl-4-hydroxy-2-(2-hydroxypropan-2-yl)-6-methyl-2,3-dihydrobenzofuran-5-carboxylate
Microorganisms are an important source of compounds that are pharmaceutically active, both as leads and as scaffolds for synthesis. Often, interesting chemistry is uncovered by exploring new biomes, of which the Chilean Atacama Desert is a prime example. This paper describes the isolation and structural characterisation, using HR-LCMS and 1D and 2D NMR, of a new compound belonging to a family of compounds called radstrictins. The compound was isolated from a fungus, that had itself been isolated from a soil sample from the Atacama Desert. The compound was tested against pathogenic strains associated with bovine mastitis, but was found to be devoid of antimicrobial activity.
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来源期刊
Molbank
Molbank Chemistry-Physical and Theoretical Chemistry
CiteScore
0.70
自引率
33.30%
发文量
174
审稿时长
11 weeks
期刊介绍: •organic synthesis •biosynthesis •extraction and purification •natural product derivatives •structural elucidation (X-ray crystallography, NMR, etc.)
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