{"title":"干细胞在癌症发生发展中的作用探讨","authors":"A. Ebrahimi, P. Abbasi, M. Cucchiarini","doi":"10.4993/acrt.28.3","DOIUrl":null,"url":null,"abstract":"Tumors comprise two types of non-cancerous cells, first recruited cells such as stem cells and macrophages, and second, tissue-steady cells that are part of the tissue including adipose cells, fibroblasts, and steady macrophage-derived cells, all having a significant impact on tumor progression. This review addresses some effects of stem cells on cancer advancement as the predominant outcome of stem cell therapy on cancer cell lines revealed controversial results. In addition, this review will address some reasons of distinct cancer responses and hypotheses the notion of unfolded protein response as a key switch in cancer development.","PeriodicalId":35647,"journal":{"name":"Annals of Cancer Research and Therapy","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2020-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4993/acrt.28.3","citationCount":"3","resultStr":"{\"title\":\"Exploring the Role of Stem Cells in Cancer Development and Progression\",\"authors\":\"A. Ebrahimi, P. Abbasi, M. Cucchiarini\",\"doi\":\"10.4993/acrt.28.3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Tumors comprise two types of non-cancerous cells, first recruited cells such as stem cells and macrophages, and second, tissue-steady cells that are part of the tissue including adipose cells, fibroblasts, and steady macrophage-derived cells, all having a significant impact on tumor progression. This review addresses some effects of stem cells on cancer advancement as the predominant outcome of stem cell therapy on cancer cell lines revealed controversial results. In addition, this review will address some reasons of distinct cancer responses and hypotheses the notion of unfolded protein response as a key switch in cancer development.\",\"PeriodicalId\":35647,\"journal\":{\"name\":\"Annals of Cancer Research and Therapy\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-01-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.4993/acrt.28.3\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annals of Cancer Research and Therapy\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4993/acrt.28.3\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of Cancer Research and Therapy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4993/acrt.28.3","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
Exploring the Role of Stem Cells in Cancer Development and Progression
Tumors comprise two types of non-cancerous cells, first recruited cells such as stem cells and macrophages, and second, tissue-steady cells that are part of the tissue including adipose cells, fibroblasts, and steady macrophage-derived cells, all having a significant impact on tumor progression. This review addresses some effects of stem cells on cancer advancement as the predominant outcome of stem cell therapy on cancer cell lines revealed controversial results. In addition, this review will address some reasons of distinct cancer responses and hypotheses the notion of unfolded protein response as a key switch in cancer development.
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