{"title":"走向人类!昼夜节律转化医学已经成熟","authors":"D. Ju, E. E. Zhang","doi":"10.26599/BSA.2020.9050013","DOIUrl":null,"url":null,"abstract":"Circadian rhythms are oscillating biological processes with a rough 24‐hour period and ubiquitously exist in most organisms living on the surface of the earth. These rhythms are manifest of the cycling transcriptome which is driven by the endogenous circadian clock. Given the clock orchestrates half of protein‐ coding genes and most physiologies in humans, it is no exaggeration to say: we are what our clock ticks. Therefore, human health lies in a harmonic relationship between our body clocks and the environment. Despite a great advancement in the molecular mechanism of the circadian clock in the last few decades, investigations on the circadian clock in human health have just emerged [1].","PeriodicalId":67062,"journal":{"name":"Brain Science Advances","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Go Human! Circadian translational medicine has come of age\",\"authors\":\"D. Ju, E. E. Zhang\",\"doi\":\"10.26599/BSA.2020.9050013\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Circadian rhythms are oscillating biological processes with a rough 24‐hour period and ubiquitously exist in most organisms living on the surface of the earth. These rhythms are manifest of the cycling transcriptome which is driven by the endogenous circadian clock. Given the clock orchestrates half of protein‐ coding genes and most physiologies in humans, it is no exaggeration to say: we are what our clock ticks. Therefore, human health lies in a harmonic relationship between our body clocks and the environment. Despite a great advancement in the molecular mechanism of the circadian clock in the last few decades, investigations on the circadian clock in human health have just emerged [1].\",\"PeriodicalId\":67062,\"journal\":{\"name\":\"Brain Science Advances\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Brain Science Advances\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.26599/BSA.2020.9050013\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Brain Science Advances","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.26599/BSA.2020.9050013","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Go Human! Circadian translational medicine has come of age
Circadian rhythms are oscillating biological processes with a rough 24‐hour period and ubiquitously exist in most organisms living on the surface of the earth. These rhythms are manifest of the cycling transcriptome which is driven by the endogenous circadian clock. Given the clock orchestrates half of protein‐ coding genes and most physiologies in humans, it is no exaggeration to say: we are what our clock ticks. Therefore, human health lies in a harmonic relationship between our body clocks and the environment. Despite a great advancement in the molecular mechanism of the circadian clock in the last few decades, investigations on the circadian clock in human health have just emerged [1].