走向人类!昼夜节律转化医学已经成熟

D. Ju, E. E. Zhang
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引用次数: 2

摘要

昼夜节律是一种振荡的生物过程,周期为24小时,普遍存在于地球表面的大多数生物中。这些节律是由内源性生物钟驱动的循环转录组的表现。考虑到时钟协调了人类一半的蛋白质编码基因和大多数生理学,可以毫不夸张地说:我们就是时钟滴答作响的人。因此,人类的健康在于我们的生物钟与环境之间的和谐关系。尽管在过去的几十年里,昼夜节律钟的分子机制取得了很大的进展,但对人类健康中昼夜节律时钟的研究才刚刚出现[1]。
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Go Human! Circadian translational medicine has come of age
Circadian rhythms are oscillating biological processes with a rough 24‐hour period and ubiquitously exist in most organisms living on the surface of the earth. These rhythms are manifest of the cycling transcriptome which is driven by the endogenous circadian clock. Given the clock orchestrates half of protein‐ coding genes and most physiologies in humans, it is no exaggeration to say: we are what our clock ticks. Therefore, human health lies in a harmonic relationship between our body clocks and the environment. Despite a great advancement in the molecular mechanism of the circadian clock in the last few decades, investigations on the circadian clock in human health have just emerged [1].
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审稿时长
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