tribles基因在结直肠癌中的表达谱

IF 0.9 Q4 GASTROENTEROLOGY & HEPATOLOGY Gastrointestinal disorders (Basel, Switzerland) Pub Date : 2021-11-09 DOI:10.3390/gidisord3040021
M. Fernandes, Victor Yassuda, J. Bragança, W. Link, Bibiana I. Ferreira, A. L. De Sousa-Coelho
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引用次数: 1

摘要

结直肠癌(CRC)是世界上第三大最常见的癌症,也是第二大癌症死亡原因。因此,迫切需要寻找新的药物靶点。Tribbles蛋白属于假激酶家族,以前在结直肠癌中被认为是癌基因和潜在的治疗靶点。在这里,我们分析了TRIB1、TRIB2和TRIB3在33个CRC数据集中同时表达的情况。我们发现所有三个tribles基因在结直肠癌细胞系和原发性肿瘤中都有过度表达,尽管这取决于结直肠癌样本的特定特征。TRIB2在肿瘤微环境中的高表达和TRIB3在CRC早期发展阶段的过表达,揭示了这些蛋白在CRC中潜在的未被探索的作用。在不同的细胞实验条件下,使用遗传或药理学方法也探索了差异tribles表达,为未来的研究提供了新的线索。这项全面的生物信息学分析为tribles基因在结直肠癌中的表达和转录调控提供了新的见解。
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Tribbles Gene Expression Profiles in Colorectal Cancer
Colorectal cancer (CRC) is the third most common cancer and the second leading cause of death due to cancer in the world. Therefore, the identification of novel druggable targets is urgently needed. Tribbles proteins belong to a pseudokinase family, previously recognized in CRC as oncogenes and potential therapeutic targets. Here, we analyzed the expression of TRIB1, TRIB2, and TRIB3 simultaneously in 33 data sets from CRC based on available GEO profiles. We show that all three Tribbles genes are overrepresented in CRC cell lines and primary tumors, though depending on specific features of the CRC samples. Higher expression of TRIB2 in the tumor microenvironment and TRIB3 overexpression in an early stage of CRC development, unveil a potential and unexplored role for these proteins in the context of CRC. Differential Tribbles expression was also explored in diverse cellular experimental conditions where either genetic or pharmacological approaches were used, providing novel hints for future research. This comprehensive bioinformatic analysis provides new insights into Tribbles gene expression and transcript regulation in CRC.
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CiteScore
1.50
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审稿时长
10 weeks
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