从发现到治愈,丙型肝炎病毒研究的伟大历程

Zhigang Yi, Zhenghong Yuan
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引用次数: 1

摘要

摘要丙型肝炎病毒(HCV)在75%以上的HCV感染者中引起慢性感染,导致大量患者患上癌症。自1989年发现以来,HCV经历了从发现到治愈的历程,这主要归功于病毒学研究和直接抗病毒药物(DAA)开发的成功。我们回顾了HCV的研究历程,从发现这种病毒到开发用于治疗的DAAs。学习丙型肝炎病毒研究中使用的方法和开发针对丙型肝炎病毒的DAA的知识可能会启发对其他难以培养的病毒的研究,如戊型肝炎病毒和诺如病毒,以及开发针对其他单链正义RNA病毒的DAAs,包括引起大流行的严重急性呼吸系统综合征冠状病毒2型病毒,其共享形成膜结合病毒复制酶的共同复制策略。
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From Discovery to Cure, A Great Journey of the Hepatitis C Virus Study
Abstract Hepatitis C virus (HCV) causes chronic infection in over 75% of the HCV-infected individuals, resulting in liver cancer in substantial patients. Since its discovery in 1989, HCV experiences a journey from discovery to cure, largely due to the virology studies and success of direct antiviral agent (DAA) development. We reviewed the HCV research journey, from the discovery of this virus to the development of DAAs for cure. Learning the methodology used in HCV studies and the knowledge of developing DAAs against HCV may inspire the studies of other difficult-to-culture viruses, such as hepatitis E virus and norovirus, as well as the development of DAAs for other single-stranded positive-sense RNA viruses, including the pandemic-causing SARS-CoV-2 virus, which shares the common replication strategy of forming a membrane-bound viral replicase.
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