膨润土对黄曲霉毒素B1和赭曲霉毒素a免疫毒性的保护作用

IF 2.4 4区 医学 Q3 TOXICOLOGY Journal of Immunotoxicology Pub Date : 2017-01-01 DOI:10.1080/1547691X.2016.1264503
S. Bhatti, M. Z. Khan, M. Saleemi, M. Saqib, Ahrar Khan, Z. Ul-Hassan
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引用次数: 42

摘要

摘要本研究旨在探讨膨润土(BN)对日粮黄曲霉毒素B1(AFB1)或赭曲霉毒素A(OTA)引起的肉鸡免疫病理改变的改善作用。在一个实验中,AFB1(0.1、0.2或0.6 mg/kg进料)单独进料,并与膨润土粘土(3.7或7.5 g/kg饲料)。在第二个实验中,肉鸡被给予OTA污染的饲料(0.15、0.3或1.0 mg/kg进料)单独和与膨润土粘土(3.7、7.5或15 g/kg饲料)。实验饲养持续42天。在喂养计划的不同时间点,评估所有组的免疫系统器官组织学状态以及宿主体液和细胞免疫反应。通过法氏囊和胸腺的组织学变化、对SRBC的抗体反应、对植物血凝素-P(PHA-P)的体内淋巴增殖反应和原位吞噬功能评估,单独添加AFB1和OTA可显著降低鸟类的免疫反应。日粮中添加BN显著改善了0.1和0.2的免疫毒性 mg/kg日粮AFB1,但水平为0.6 mg AFB1/kg,仅观察到部分改善。暴露于OTA的鸟类与BN在所有水平上的联合治疗仅部分减轻了对组织学和免疫反应的有害影响。总之,这里的结果向我们表明,在饮食中添加BN可以帮助改善AFB1介导的免疫毒性,但不能提供对OTA诱导的免疫损伤的保护。
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Protective role of bentonite against aflatoxin B1- and ochratoxin A-induced immunotoxicity in broilers
Abstract The present study was designed to investigate any ameliorative effects of bentonite (BN) against immuno-pathological alterations induced by dietary aflatoxin B1 (AFB1) or ochratoxin A (OTA) in broiler chicks. In one experiment, AFB1 (0.1, 0.2 or 0.6 mg/kg feed) was fed alone and par alley with bentonite clay (3.7 or 7.5 g/kg feed) to the broilers. In the second experiment, the broilers were given feed contaminated with OTA (0.15, 0.3 or 1.0 mg/kg feed) alone and in combination with bentonite clay (3.7, 7.5, or 15 g/kg feed). Experimental feedings were continued for 42 days. At various time points along the feeding schedule, immune system organ histologic status, as well as host humoral and cellular immune responses, were evaluated in all groups. The dietary addition of AFB1 and OTA alone significantly reduced immune responses in the birds as assessed by histological changes in the bursa of Fabricius and thymus, antibody responses to SRBC, in-vivo lympho-proliferative responses to Phytohemagglutinin-P (PHA-P) and, phagocytic function in situ. The dietary addition of BN significantly ameliorated the immunotoxicity of 0.1 and 0.2 mg/kg dietary AFB1, however with a level of 0.6 mg AFB1/kg only partial amelioration was seen. The co-treatment of birds exposed to OTA with BN at all levels only partially alleviated deleterious effects on histology and immune responses. Taken together, the results here suggested to us that dietary addition of BN could help ameliorate AFB1-mediated immunotoxicities but could not afford such protection against OTA-induced immune damage.
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来源期刊
Journal of Immunotoxicology
Journal of Immunotoxicology 医学-毒理学
CiteScore
6.70
自引率
3.00%
发文量
26
审稿时长
1 months
期刊介绍: The Journal of Immunotoxicology is an open access, peer-reviewed journal that provides a needed singular forum for the international community of immunotoxicologists, immunologists, and toxicologists working in academia, government, consulting, and industry to both publish their original research and be made aware of the research findings of their colleagues in a timely manner. Research from many subdisciplines are presented in the journal, including the areas of molecular, developmental, pulmonary, regulatory, nutritional, mechanistic, wildlife, and environmental immunotoxicology, immunology, and toxicology. Original research articles as well as timely comprehensive reviews are published.
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