支气管肺发育不良的表观遗传机制综述

Q4 Medicine 中华围产医学杂志 Pub Date : 2020-01-16 DOI:10.3760/CMA.J.ISSN.1007-9408.2020.01.011

Peijuan Chen, Zhiting Wan, Bao-huan Cai, Wenbin Li

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引用次数: 0

摘要

支气管肺发育不良（BPD）是早产儿常见的慢性呼吸道并发症，在不完全了解其发病机制或有效治疗的情况下，可能会严重影响这些婴儿的生存率和预后。研究证实，表观遗传学机制，包括组蛋白修饰、非编码RNA和DNA甲基化，可能在BPD的发病和发展中发挥重要作用。大多数相关的表观遗传学变化是可逆的，这可能是BPD治疗的潜在靶点。因此，对表观遗传学的进一步研究将有助于更好地了解BPD的发病机制、预防和治疗。关键词：支气管肺发育不良；表观基因组学；直方图编码；RNA，未翻译；DNA甲基化

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Epigenetic mechanisms of bronchopulmonary dysplasia: a review

Bronchopulmonary dysplasia (BPD) is a common chronic respiratory complication in preterm infants without fully understand the mechanism or effective treatment, which could significantly affect the survival rate and prognosis of these infants. Studies have confirmed that epigenetic mechanisms, including histone modification, non-coding RNA and DNA methylation may play an essential role in the onset and development of BPD. And most related epigenetic changes are reversible, which might serve as a potential target for BPD treatment. Therefore, further studies on epigenetics will shed light on a better understanding of the pathogenesis, prevention, and treatment of BPD. Key words: Bronchopulmonary dysplasia; Epigenomics; Histone code; RNA, untranslated; DNA methylation

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