NFDI4Microbiota -微生物群研究的国家研究数据基础设施

Konrad U. Förstner, A. Becker, J. Blom, P. Bork, T. Clavel, M. Dieckmann, A. Goesmann, B. Götz, T. Gübitz, Franziska Hufsky, Sebastian Jünemann, Marie-Louise Körner, M. Marz, U. N. da Rocha, Jörg Overmann, A. Pühler, D. Rebholz-Schuhmann, A. Sczyrba, J. Stoye, Justine Vandendorpe, T. Van Rossum, A. Mchardy
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引用次数: 0

摘要

微生物——细菌、古菌、单细胞真核生物和病毒——在人类和环境健康中发挥着重要作用。对这一事实的日益认识导致微生物学研究和应用在各个领域的巨大增长。在允许对微生物物种和群落进行高通量分子表征的技术进步的推动下,微生物学研究现在为满足当前和新出现的需求提供了无与伦比的机会。除了帮助应对抗微生物耐药性和病毒大流行等全球健康威胁外,它还在农业、废物管理、水处理、生态系统修复以及各种疾病的诊断、治疗和预防等领域发挥着关键作用。反映出这种广泛的潜力,全球已在微生物群研究项目上投资数十亿欧元。尽管这些项目是独立运行的,但其中许多项目是密切相关的。然而,德国目前没有基础设施来连接这些项目,甚至没有比较它们的结果。因此,数据和专业知识的潜在协同作用正在被浪费。NFDI4微生物群联盟的目标是通过专门的培训提高研究结果的可用性和质量,并促进微生物数据的生成、管理、解释、共享和再利用,从而服务和连接这个广泛而异质的研究社区。通过这样做,我们还将促进研究人员之间的跨学科互动。NFDI4微生物群将通过培训和社区建设活动创建一个德国微生物研究网络,并创建一个基于云的系统,使微生物数据,特别是组学数据的存储、集成和分析在生命科学的所有领域保持一致、可复制和可访问,从而实现这一目标。除了提高德国微生物研究的质量外,我们的培训计划还将支持这些服务的广泛和正确使用。通过对教育和服务的双重重视,NFDI4微生物群将确保德国的微生物研究具有协同性和高效性,因此非常出色。通过为德国微生物研究创建一个中心资源,NDFDI4Microbiota将为所有从事微生物数据工作的NFDI联盟建立一个连接中心,包括GHGA、NFDI4Bioversity、NFDI4Agri和其他几个。NFDI4Microbiota将为这些联盟的非微生物专家提供直接和方便的微生物研究所需的专业知识和基础设施,以促进他们的日常工作并加强他们的研究。通过NFDI4微生物群建立的联系不仅将增加NFDI联盟之间的协同作用,还将提高德国微生物研究的整体质量和相关性。
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NFDI4Microbiota – national research data infrastructure for microbiota research
Microbes – bacteria, archaea, unicellular eukaryotes, and viruses – play an important role in human and environmental health. Growing awareness of this fact has led to a huge increase in microbiological research and applications in a variety of fields. Driven by technological advances that allow high-throughput molecular characterization of microbial species and communities, microbiological research now offers unparalleled opportunities to address current and emerging needs. As well as helping to address global health threats such as antimicrobial resistance and viral pandemics, it also has a key role to play in areas such as agriculture, waste management, water treatment, ecosystems remediation, and the diagnosis, treatment and prevention of various diseases. Reflecting this broad potential, billions of euros have been invested in microbiota research programs worldwide. Though run independently, many of these projects are closely related. However, Germany currently has no infrastructure to connect such projects or even compare their results. Thus, the potential synergy of data and expertise is being squandered. The goal of the NFDI4Microbiota consortium is to serve and connect this broad and heterogeneous research community by elevating the availability and quality of research results through dedicated training, and by facilitating the generation, management, interpretation, sharing, and reuse of microbial data. In doing so, we will also foster interdisciplinary interactions between researchers. NFDI4Microbiota will achieve this by creating a German microbial research network through training and community-building activities, and by creating a cloud-based system that will make the storage, integration and analysis of microbial data, especially omics data, consistent, reproducible, and accessible across all areas of life sciences. In addition to increasing the quality of microbial research in Germany, our training program will support widespread and proper usage of these services. Through this dual emphasis on education and services, NFDI4Microbiota will ensure that microbial research in Germany is synergistic and efficient, and thus excellent. By creating a central resource for German microbial research, NDFDI4Microbiota will establish a connecting hub for all NFDI consortia that work with microbiological data, including GHGA, NFDI4Biodiversity, NFDI4Agri and several others. NFDI4Microbiota will provide non-microbial specialists from these consortia with direct and easy access to the necessary expertise and infrastructure in microbial research in order to facilitate their daily work and enhance their research. The links forged through NFDI4Microbiota will not only increase the synergy between NFDI consortia, but also elevate the overall quality and relevance of microbial research in Germany.
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