富含血小板的血浆和间充质干细胞作为两种生物替代物在旋转袖带损伤治疗中的作用:综述

Mohsen Sheykhhasan, Hamed Manoochehri, Pouria Samadi, R. Fotouhi-Ardakani, N. Kalhor
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引用次数: 1

摘要

肩袖损伤作为创伤等因素的重要损伤引入,是目前公认的骨科普遍存在的问题。因此,许多临床手术已被证明可以减少肩袖损伤的并发症,并取得了不同程度的成功。富血小板血浆(PRP)被公认为是治疗肩袖损伤最有效的治疗策略之一。许多令人困惑的参数会影响PRP的结果,包括肩袖损伤的大小、患者年龄、PRP产生策略以及PRP注射的次数和时间。然而,与皮质类固醇和其他非手术方法相比,有一些证据支持PRP在长期缓解疼痛和恢复功能方面的有益效果,以及最小的不良反应。除了富含血小板的血浆外,间充质干细胞(MSC)是另一种可用于治疗肩袖损伤的生物替代品。由于缺乏大型临床试验的适用性,这些生物细胞面临着与PRP相当相似的挑战。总之,有必要进行进一步的研究,以了解这两种替代方案作为肩袖损伤安全有效的治疗选择的潜在应用。A B S T R A C T
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Effect of Platelet-rich Plasma and Mesenchymal Stem Cells as Two Biological Alternatives in Rotator Cuff Injury Treatment: A Mini-review
The rotator cuff injury introduces as significant damage of trauma and others factors, and currently recognized as a prevalent orthopedic problem. Thus, many clinical procedures have been demonstrated to reduce the complication of rotator cuff injury with varying degrees of success. Platelet-Rich Plasma (PRP) is being enchantingly agreed as one of the most effectiveness strategies for the symptomatic treatment of rotator cuff injury. Many confusing parameters can influence the result of PRP including size of rotator cuff injury, patient age, PRP producing strategy, and number and timing of PRP injections. However, there is some evidences which support beneficial effect PRP in term relieving pain and restoring function, along with minimal adverse effect, in compared with corticosteroids, and other nonsurgical methods. Besides platelet-rich plasma, Mesenchymal Stem Cells (MSCs) are another biological alternative that can be used to treat rotator cuff injuries. Due to lack of large clinical trials applicability, these biological cells have challenges fairly similar to PRP. In conclusion, there is a need for further research to understand the potential application of both of these alternatives as a safe and effective therapeutic option for rotator cuff injuries. A B S T R A C T
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