天然螯合剂对铅中毒大鼠肝毒性的减轻作用

IF 0.7 Q4 PHARMACOLOGY & PHARMACY Journal of Reports in Pharmaceutical Sciences Pub Date : 2022-07-01 DOI:10.4103/jrptps.jrptps_44_22
Q. Nausheen, Syed Ali
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引用次数: 0

摘要

目的:本研究旨在监测铅对人体的影响,天然螯合剂(壳聚糖和壳多胺)对铅的逆转作用,以及单药治疗与合成药物联合治疗的比较。材料和方法:将42只白化Wistar雄性大鼠(200–250 g)分为7组(n=6)。除第一组接受1g/L乙酸钠(饮用水,载体对照)外,所有组均接受0.4mg/kg体重口服醋酸铅。第二组(毒性)仅接受醋酸铅,而第三组和第四组分别接受0.2g/kg壳聚糖和壳多胺。第V-VII组接受乙二胺四乙酸(EDTA)495 mg/kg(p.o.)。此外,第六组和第七组分别接受壳聚糖和壳多胺(0.2 g/kg)(p.o.)。评估血液学、生化、氧化应激参数、形成的卟啉原分子数/h/mL和组织病理学。使用Tukey检验后的方差分析对获得的数据进行比较。结果:与对照组和治疗组相比,毒性组的血象参数、抗氧化酶、卟啉原分子显著降低,氧化应激、肝脏生物标志物以及丙二醛增加。组织病理学结果显示,与毒性组相比,壳聚糖和壳多胺治疗组有显著改善,而联合治疗的单药治疗结果比单药治疗最显著。结论:壳聚糖和壳多胺可通过螯合作用改善血液和肝脏毒性,可作为重金属毒性的有效解毒剂。
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Alleviation of hepatotoxicity by natural chelators in lead-induced poisoning in rats
Aims: The study intends to monitor the consequences of lead on the body, its reversal by natural chelators (chitosan and chitosamine), and comparison of monotherapy with the combination using the synthetic ones. Materials and Methods: A total of 42 albino Wistar male rats (200–250 g) were divided into seven groups (n = 6). Except for the first group which received sodium acetate 1 g/L (drinking water, vehicle control), all groups received lead acetate 0.4 mg/kg body weight peroral (p.o.). Group II (toxic) received merely lead acetate, whereas the third and fourth groups received 0.2 g/kg (p.o.) of chitosan and chitosamine, respectively. Groups V–VII received ethylenediaminetetraacetic acid (EDTA) 495 mg/kg (p.o.). In addition, the sixth and seventh groups received chitosan and chitosamine (0.2 g/kg) (p.o.), respectively. The hematological, biochemical, oxidative stress parameters, number of porphobilinogen molecules formed/h/mL, and histopathology were assessed. The data obtained were compared using analysis of variance following Tukey’s test. Results: The results revealed a statistically significant reduction in the hemogram parameters, antioxidant enzymes, porphobilinogen molecules and an increase in oxidative stress, liver biomarkers along with malondialdehyde in the toxic group in comparison with control and treatment groups. The histopathological findings revealed a significant improvement in the chitosan and chitosamine treatment groups when compared with the toxic group, whereas the results obtained from combination therapy with respect to its monotherapy were most significant than the monotherapy alone. Conclusion: Chitosan and chitosamine are found to improve hemato- and hepatotoxicity by chelation and can be used as potent detoxifiers in heavy metal toxicities.
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来源期刊
Journal of Reports in Pharmaceutical Sciences
Journal of Reports in Pharmaceutical Sciences Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)
CiteScore
1.40
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期刊介绍: The Journal of Reports in Pharmaceutical Sciences(JRPS) is a biannually peer-reviewed multi-disciplinary pharmaceutical publication to serve as a means for scientific information exchange in the international pharmaceutical forum. It accepts novel findings that contribute to advancement of scientific knowledge in pharmaceutical fields that not published or under consideration for publication anywhere else for publication in JRPS as original research article. all aspects of pharmaceutical sciences consist of medicinal chemistry, molecular modeling, drug design, pharmaceutics, biopharmacy, pharmaceutical nanotechnology, pharmacognosy, natural products, pharmaceutical biotechnology, pharmacology, toxicology and clinical pharmacy.
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