在南印度,低BMI的中心性肥胖是新冠肺炎严重程度的危险因素。

IF 1.3 4区 医学 Q4 NUTRITION & DIETETICS Asia Pacific journal of clinical nutrition Pub Date : 2022-03-01 DOI:10.6133/apjcn.202203_31(1).0015
Shalini G Hegde, Shashank Dhareshwar, Sulagna Bandyopadhyay, Rebecca R Kuriyan, Jyothi Idiculla, Santu Ghosh, Anura V Kurpad, Nirupama Shivakumar
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引用次数: 0

摘要

背景和目的众所周知,南亚人在较低的体重指数下有过度肥胖,躯干脂肪堆积。这是否会增加患严重新冠肺炎的风险尚不清楚。这项研究评估了南亚成年人的体重指数、体脂肪量和腰围是新冠肺炎严重程度及其进展的危险因素。方法和研究设计前瞻性地获得新冠肺炎患者(19-90岁)的详细信息,以及通过生物电阻抗分析评估的体重、身高、腰围和体脂肪量。采用二项式逻辑回归和泊松回归检验腰围、体脂量和体重指数之间的相关性,以评估入院时疾病严重程度和住院时间的调整OR或相对风险。结果在校正了年龄、性别、身高和合并症后,体重指数>23kg/m2(校正OR 2.758,95%CI 1.025,7.427)、腰围(校正OR 1.047,95%CI 1.002,1.093)和体脂量(校正OR 1.111,95%CI 1.013,1.219)与入院时疾病严重程度的显著风险相关,而只有腰围(调整后的相对风险1.004,95%CI 1.001,1.008)和体脂量(调整后相对风险1.011,95%CI 1.00 3,1.018)与住院时间显著延长有关。结论在研究的患者组中,体重指数(下限>23kg/m2)是新冠肺炎疾病严重程度的重要危险因素。腰围和体脂量也是衡量入院时严重程度和住院时间的良好指标。
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Central obesity in low BMI as a risk factor for COVID-19 severity in South Indians.

Background and objectives: South Asians are known to have excess adiposity at a lower body mass index, with truncal fat accumulation. Whether this confers higher risk to develop severe COVID-19 is not known. This study evaluated body mass index, body fat mass and waist circumference as risk factors for COVID-19 severity and its progression, in South Asian adults.

Methods and study design: Details of COVID-19 patients (19-90 years) were obtained prospectively, along with weight, height, waist circumference and body fat mass assessed by bioelectrical impedance analysis. Binomial logistic and Poisson regression were performed to test associations between waist circumference, body fat mass and body mass index to evaluate the adjusted OR or relative risk for disease severity at admission and length of stay.

Results: After adjusting for age, sex, height and co-morbidities, body mass index >23 kg/m2 (adjusted OR 2.758, 95% CI 1.025, 7.427), waist circumference (adjusted OR 1.047, 95% CI 1.002, 1.093) and body fat mass (adjusted OR 1.111, 95% CI 1.013, 1.219) were associated with a significant risk for disease severity at admission, while only waist circumference (adjusted relative risk 1.004, 95% CI 1.001, 1.008), and body fat mass (adjusted relative risk 1.011, 95% CI 1.003, 1.018), were associated with a significantly longer length of stay.

Conclusions: Body mass index, at a lower cut-off of >23 kg/m2, is a significant risk factor for COVID-19 disease severity in the group of patients studied. The waist circumference and body fat mass are also good indicators for both severity at admission and length of stay.

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来源期刊
CiteScore
2.50
自引率
7.70%
发文量
58
审稿时长
6-12 weeks
期刊介绍: The aims of the Asia Pacific Journal of Clinical Nutrition (APJCN) are to publish high quality clinical nutrition relevant research findings which can build the capacity of clinical nutritionists in the region and enhance the practice of human nutrition and related disciplines for health promotion and disease prevention. APJCN will publish original research reports, reviews, short communications and case reports. News, book reviews and other items will also be included. The acceptance criteria for all papers are the quality and originality of the research and its significance to our readership. Except where otherwise stated, manuscripts are peer-reviewed by at least two anonymous reviewers and the Editor. The Editorial Board reserves the right to refuse any material for publication and advises that authors should retain copies of submitted manuscripts and correspondence as material cannot be returned. Final acceptance or rejection rests with the Editorial Board
期刊最新文献
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