具有二肽链的6-氧茚-1-酮

IF 0.4 Q4 CHEMISTRY, ANALYTICAL French-Ukrainian Journal of Chemistry Pub Date : 2019-12-24 DOI:10.17721/fujcv7i2p111-119
S. Shilin, O. Shablykina, Igor V. Levkov, O. Bugera, Z. Voitenko
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引用次数: 0

摘要

采用N-羟基琥珀酰亚胺酯法,通过2-(3-氧代-2,3-二氢-1H-茚-5-基氧基)乙酸对a-或b-氨基酸单元进行N-酰化反应,得到了新的二肽茚-1-酮衍生物。通常,底物的乙酸羧基与a-或b-二肽的氨基的直接相互作用是比两个氨基酸的顺序肽缩合更有效的策略。
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6-Oxyindan-1-ones with dipeptide chains
Through N-acylation of a- or b-amino acid units by 2-(3-oxo-2,3-dihydro-1H-inden-5-yloxy)acetic acid using the method of N-hydroxysuccinimide esters new dipeptide indan-1-one derivatives were obtained. In general, the direct interaction of the acetic carboxyl group of the substrate with the amino group of the a- or b-dipeptide is a more productive strategy than the sequential peptidic condensation of the two amino acids.
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来源期刊
French-Ukrainian Journal of Chemistry
French-Ukrainian Journal of Chemistry CHEMISTRY, ANALYTICAL-
自引率
0.00%
发文量
13
审稿时长
4 weeks
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