在中国青岛的社区老年人中,支链和其他氨基酸的摄入与少肌症呈负相关。

IF 1.3 4区 医学 Q4 NUTRITION & DIETETICS Asia Pacific journal of clinical nutrition Pub Date : 2022-03-01 DOI:10.6133/apjcn.202203_31(1).0011
MM Wen-junMa, Wei Zhang, Jie-Yi Zhai, Hui Li, T. Zhao, Lei Han Dr, Qian Wen, Xu-Dong Song, Xiao Guo
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引用次数: 1

摘要

背景和目的本研究旨在通过一项基于社区的观察性研究来调查饮食氨基酸摄入与少肌症风险相关的假设。方法和研究设计从中国青岛的年度健康检查项目中招募了1140名参与者(72.7±6.3y)。采用标准方法测定骨骼肌质量、肌肉质量功能和生化参数。通过3天24小时的食物记录来评估饮食摄入量。使用多变量调整的逻辑回归模型计算氨基酸摄入量四分位数的肌萎缩风险的比值比(OR)和95%置信区间(CI)。使用广义线性模型来评估膳食氨基酸摄入量与肌肉质量功能之间的关系。结果少肌症的患病率为4.1%。与最低类别摄入量、最高类别支链氨基酸(BCAAs)相比(OR=0.11;95%CI:0.01,0.90;趋势p=0.119),异亮氨酸(OR=0.11;95%可信区间:0.010.89;趋势p=0.122)和色氨酸(OR=0.10;95%可信范围:0.010.87;趋势p=0.176)与肌萎缩风险呈负相关,并对潜在的混杂因素进行了调整。广义线性模型分析表明,步态速度与赖氨酸、苏氨酸、亮氨酸、缬氨酸、色氨酸、支链氨基酸和芳香族氨基酸的摄入量呈正相关(p<0.05)。
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Branched chain and other amino acid intakes are inversely associated with sarcopenia among community elders in Qingdao, China.
BACKGROUND AND OBJECTIVES The present study aimed to investigate the hypothesis that dietary amino acid intakes are associated with the risk of sarcopenia through a community-based observational study. METHODS AND STUDY DESIGN A total of 1,140 participants (72.7±6.3 y) were recruited from an annual health check-up program in Qingdao, China. Skeletal muscle mass, muscle mass functions and biochemical parameters were measured by standard methods. Dietary intake was assessed by 3-day, 24-hour food records. The odds ratios (ORs) and 95% confidence intervals (CIs) of sarcopenic risk across quartiles of amino acid intakes were calculated using a multivariable- adjusted logistic regression model. Generalized linear models were used to assess the associations between dietary amino acid intakes and muscle mass functions. RESULTS The prevalence of sarcopenia was 4.1%. Compared with the lowest category intake, the highest category of branched chain amino acids (BCAAs) (OR=0.11; 95% CI: 0.01, 0.90; p for trend=0.119), isoleucine (OR=0.11; 95% CI: 0.01, 0.89; p for trend=0.122) and tryptophan (OR=0.10; 95% CI: 0.01, 0.87; p for trend=0.176) was negatively correlated with sarcopenic risk with adjustment for potential confounding factors. Generalized linear model analysis showed that gait speed was positively correlated with dietary intakes of lysine, threonine, leucine, valine, tryptophan, BCAAs and aromatic amino acids (p<0.05). CONCLUSIONS Higher intakes of BCAAs were associated with a lower risk of sarcopenia, which might beneficially protect against sarcopenia and improve physical function of the elderly.
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来源期刊
CiteScore
2.50
自引率
7.70%
发文量
58
审稿时长
6-12 weeks
期刊介绍: The aims of the Asia Pacific Journal of Clinical Nutrition (APJCN) are to publish high quality clinical nutrition relevant research findings which can build the capacity of clinical nutritionists in the region and enhance the practice of human nutrition and related disciplines for health promotion and disease prevention. APJCN will publish original research reports, reviews, short communications and case reports. News, book reviews and other items will also be included. The acceptance criteria for all papers are the quality and originality of the research and its significance to our readership. Except where otherwise stated, manuscripts are peer-reviewed by at least two anonymous reviewers and the Editor. The Editorial Board reserves the right to refuse any material for publication and advises that authors should retain copies of submitted manuscripts and correspondence as material cannot be returned. Final acceptance or rejection rests with the Editorial Board
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