Haibo Feng , Hui Zhi , Xin Hu , Yan Yang , Linzi Zhang , Qianqian Liu , Yangyang Feng , Daiyan Wu , Xiaonong Yang
{"title":"巴戟天的免疫学研究:多糖如何作为佐剂","authors":"Haibo Feng , Hui Zhi , Xin Hu , Yan Yang , Linzi Zhang , Qianqian Liu , Yangyang Feng , Daiyan Wu , Xiaonong Yang","doi":"10.1080/07328303.2021.1954657","DOIUrl":null,"url":null,"abstract":"<div><p><em>Morinda officinalis</em> polysaccharides (MOPS) were investigated for their physicochemical properties, monosaccharide composition, and immune-modulating effects <em>in vitro</em> and <em>in vivo</em>. <em>In vitro</em>, MOPS significantly promoted lymphocyte proliferation and increased IFN-γ and IL-4 secretion. <em>In vivo</em>, MOPS acted as adjuvant, which significantly up-regulated HBsAg-specific IgG and IgG isotype levels, promoted antigen-specific T cell proliferation and cytokine (IL-2 and IL-5) production, and induced CTL and NK cytotoxicity. Moreover, MOPS increased DC maturation. Overall, MOPS can serve as an adjuvant to promote humoral and cellular immune responses via promoting DC maturation, suggesting that MOPS may have potentials as a natural immune-enhancing agent.</p><p><span><figure><span><img><ol><li><span>Download : <span>Download high-res image (850KB)</span></span></li><li><span>Download : <span>Download full-size image</span></span></li></ol></span></figure></span></p></div>","PeriodicalId":15311,"journal":{"name":"Journal of Carbohydrate Chemistry","volume":"40 4","pages":"Pages 156-178"},"PeriodicalIF":1.2000,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/07328303.2021.1954657","citationCount":"2","resultStr":"{\"title\":\"Immunological studies of Morinda officinalis: How polysaccharides act as adjuvants\",\"authors\":\"Haibo Feng , Hui Zhi , Xin Hu , Yan Yang , Linzi Zhang , Qianqian Liu , Yangyang Feng , Daiyan Wu , Xiaonong Yang\",\"doi\":\"10.1080/07328303.2021.1954657\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><em>Morinda officinalis</em> polysaccharides (MOPS) were investigated for their physicochemical properties, monosaccharide composition, and immune-modulating effects <em>in vitro</em> and <em>in vivo</em>. <em>In vitro</em>, MOPS significantly promoted lymphocyte proliferation and increased IFN-γ and IL-4 secretion. <em>In vivo</em>, MOPS acted as adjuvant, which significantly up-regulated HBsAg-specific IgG and IgG isotype levels, promoted antigen-specific T cell proliferation and cytokine (IL-2 and IL-5) production, and induced CTL and NK cytotoxicity. Moreover, MOPS increased DC maturation. Overall, MOPS can serve as an adjuvant to promote humoral and cellular immune responses via promoting DC maturation, suggesting that MOPS may have potentials as a natural immune-enhancing agent.</p><p><span><figure><span><img><ol><li><span>Download : <span>Download high-res image (850KB)</span></span></li><li><span>Download : <span>Download full-size image</span></span></li></ol></span></figure></span></p></div>\",\"PeriodicalId\":15311,\"journal\":{\"name\":\"Journal of Carbohydrate Chemistry\",\"volume\":\"40 4\",\"pages\":\"Pages 156-178\"},\"PeriodicalIF\":1.2000,\"publicationDate\":\"2021-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1080/07328303.2021.1954657\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Carbohydrate Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/org/science/article/pii/S0732830322000027\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Carbohydrate Chemistry","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S0732830322000027","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Immunological studies of Morinda officinalis: How polysaccharides act as adjuvants
Morinda officinalis polysaccharides (MOPS) were investigated for their physicochemical properties, monosaccharide composition, and immune-modulating effects in vitro and in vivo. In vitro, MOPS significantly promoted lymphocyte proliferation and increased IFN-γ and IL-4 secretion. In vivo, MOPS acted as adjuvant, which significantly up-regulated HBsAg-specific IgG and IgG isotype levels, promoted antigen-specific T cell proliferation and cytokine (IL-2 and IL-5) production, and induced CTL and NK cytotoxicity. Moreover, MOPS increased DC maturation. Overall, MOPS can serve as an adjuvant to promote humoral and cellular immune responses via promoting DC maturation, suggesting that MOPS may have potentials as a natural immune-enhancing agent.
期刊介绍：
The Journal of Carbohydrate Chemistry serves as an international forum for research advances involving the chemistry and biology of carbohydrates. The following aspects are considered to fall within the scope of this journal:
-novel synthetic methods involving carbohydrates, oligosaccharides, and glycoconjugates-
the use of chemical methods to address aspects of glycobiology-
spectroscopic and crystallographic structure studies of carbohydrates-
computational and molecular modeling studies-
physicochemical studies involving carbohydrates and the chemistry and biochemistry of carbohydrate polymers.
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