苜蓿改善环磷酰胺诱导的大鼠血小板减少和氧化应激

IF 3.3 4区医学 Q2 TOXICOLOGY Toxin Reviews Pub Date : 2023-02-14 DOI:10.1080/15569543.2023.2175870

Z. Gholamnezhad, V. Rouki, R. Rezaee, M. Boskabady

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引用次数: 1

摘要

摘要在以下大鼠中评价了紫花苜蓿（MS）水乙醇提取物对环磷酰胺（CP）诱导的毒性的影响：对照；CP（100 mg/kg皮下注射，第1-3天）；和CP+MS100、200和400 mg/kg/天，口服14 天。分析血液学、脂质、肝脏和氧化应激标志物。CP组血小板、白细胞、红细胞、Hb、Hct均低于对照组。MS200和MS400组的脂质、肝酶、亚硝酸盐和丙二醛水平低于CP组，但血小板、WBC、硫醇、超氧化物歧化酶和过氧化氢酶水平高于CP组。MS改善了CP诱导的血小板减少、氧化应激以及血脂和肝酶的增加。

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Medicago sativa ameliorated cyclophosphamide-induced thrombocytopenia and oxidative stress in rats

Abstract Effect of Medicago sativa (MS) hydro-ethanolic extract against the cyclophosphamide (CP)-induced toxicity was evaluated in rats grouped as: Control; CP (100 mg/kg subcutaneous, day 1–3); and CP+ MS100, 200, and 400 mg/kg/day, orally for 14 days. Hematologic, lipid, hepatic and oxidative stress markers were analyzed. Platelet, WBC, RBC, Hb and Hct in the CP group were lower than the control. The MS200 and MS400 groups had lower lipids, liver enzymes, nitrite and malondialdehyde levels but higher platelet, WBC, thiol, superoxide dismutase and catalase levels than the CP group. MS ameliorated CP-induced thrombocytopenia, oxidative stress, and increases in serum lipids and hepatic enzymes.

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来源期刊

Toxin Reviews 医学-毒理学

CiteScore

6.80

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Toxin Reviews provides an international forum for publishing state-of-the-art reviews and guest-edited single topic special issues covering the multidisciplinary research in the area of toxins derived from animals, plants and microorganisms. Our aim is to publish reviews that are of broad interest and importance to the toxinology as well as other life science communities. Toxin Reviews aims to encourage scientists to highlight the contribution of toxins as research tools in deciphering molecular and cellular mechanisms, and as prototypes of therapeutic agents. Reviews should emphasize the role of toxins in enhancing our fundamental understanding of life sciences, protein chemistry, structural biology, pharmacology, clinical toxinology and evolution. Prominence will be given to reviews that propose new ideas or approaches and further the knowledge of toxinology.