随机接受计算机辅助认知行为治疗或标准社区护理的焦虑儿童治疗结果的预测因素和调节因素。

IF 1.5 4区 医学 Q2 PEDIATRICS Journal of child and adolescent psychopharmacology Pub Date : 2023-10-01 DOI:10.1089/cap.2023.0019
Orri Smárason, Andrew G Guzick, Wayne K Goodman, Alison Salloum, Eric A Storch
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引用次数: 0

摘要

引言:儿童焦虑症的计算机辅助认知行为疗法(CCBT)可能有助于CBT的传播,同时保持治疗的保真度。尽管CCBT是一种有效的干预措施,但并不是每个人都能平等地从治疗中受益。识别患者特征,预测谁将从治疗中受益,以及在多大程度上有助于将患者与合适的干预措施相匹配,并使研究人员和临床医生能够更有效地修改和个性化他们的治疗形式。这些预测因素和调节因素尚未对焦虑儿童的CCBT结果进行检查,对更传统的治疗方式的研究也产生了不一致的结果。方法:利用一项评估CCBT治疗焦虑症儿童的随机临床试验的数据,本研究对100名儿童(年龄:平均[M] = 9.82,标准偏差[SD] = 1.82),随机分为CCBT(n = 49)或标准社区护理(n = 51)。从文献中确定了潜在的预测因素和调节因素,并在逐步多元线性回归模型中进行了检验,使用治疗后焦虑严重程度和整体损伤作为结果。结果:父母评定的内化症状预测了两个治疗组治疗后焦虑的严重程度。接受社区护理的组在治疗前焦虑严重程度较高,可预测治疗后整体损伤较高,但CCBT组则不然。结论:需要进一步的研究来明确哪些患者特征与CCBT结果相关。ClinicalTrials.gov标识符:NCT01416805。
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Predictors and Moderators of Treatment Outcomes for Anxious Children Randomized to Computer-Assisted Cognitive Behavioral Therapy or Standard Community Care.

Introduction: Computer-assisted cognitive behavioral therapy (CCBT) for childhood anxiety disorders may aid the dissemination of CBT, while maintaining treatment fidelity. Although CCBT is an effective intervention, not everyone benefits equally from treatment. Identifying patient characteristics that predict who will benefit from treatment and to what extent can help with matching patients to suitable interventions, and allow researchers and clinicians to modify, and individualize, their treatment formats more effectively. Such predictors and moderators have not yet been examined for CCBT outcomes in anxious children and studies of more traditional treatment formats have yielded inconsistent results. Methods: Using data from a randomized clinical trial evaluating CCBT for children with anxiety disorders, this study examined predictors and moderators of treatment outcomes in a sample of 100 children (age: mean [M] = 9.82, standard deviation [SD] = 1.82), randomized to either CCBT (n = 49) or standard community care (n = 51). Potential predictors and moderators were identified from the literature and examined in stepwise multiple linear regression models, using posttreatment anxiety severity and global impairment as outcomes. Results: Parent-rated internalizing symptoms predicted posttreatment anxiety severity for both treatment groups. High pretreatment levels of anxiety severity predicted higher global impairment at posttreatment for the group receiving community care, but not for the CCBT group. Conclusion: Further research is needed to clarify which patient characteristics are associated with CCBT outcomes in a consistent way. ClinicalTrials.gov identifier: NCT01416805.

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来源期刊
CiteScore
3.60
自引率
5.30%
发文量
61
审稿时长
>12 weeks
期刊介绍: Journal of Child and Adolescent Psychopharmacology (JCAP) is the premier peer-reviewed journal covering the clinical aspects of treating this patient population with psychotropic medications including side effects and interactions, standard doses, and research on new and existing medications. The Journal includes information on related areas of medical sciences such as advances in developmental pharmacokinetics, developmental neuroscience, metabolism, nutrition, molecular genetics, and more. Journal of Child and Adolescent Psychopharmacology coverage includes: New drugs and treatment strategies including the use of psycho-stimulants, selective serotonin reuptake inhibitors, mood stabilizers, and atypical antipsychotics New developments in the diagnosis and treatment of ADHD, anxiety disorders, schizophrenia, autism spectrum disorders, bipolar disorder, eating disorders, along with other disorders Reports of common and rare Treatment Emergent Adverse Events (TEAEs) including: hyperprolactinemia, galactorrhea, weight gain/loss, metabolic syndrome, dyslipidemia, switching phenomena, sudden death, and the potential increase of suicide. Outcomes research.
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