大肠癌治疗性生物标志物的病理学评价。

Esther Baranov MD, Jonathan A. Nowak MD, PhD
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引用次数: 0

摘要

分子检测是结直肠癌病理评估的重要组成部分,可提供诊断、预后和预测性治疗信息。所有肿瘤都需要进行错配修复状态评估。晚期和转移性肿瘤还需要确定肿瘤突变负荷、KRAS、NRAS和BRAF突变状态、ERBB2扩增状态以及NTRK和RET基因重排状态,以指导治疗。通常需要多种检测,包括免疫组织化学、微卫星不稳定性检测、MLH1启动子甲基化和下一代测序。病理学家必须意识到这些要求,以便对组织进行最佳分类。结直肠癌癌症分子诊断的进展将继续推动结直肠癌癌症个性化治疗的改进。
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来源期刊
Surgical Pathology Clinics
Surgical Pathology Clinics Medicine-Surgery
CiteScore
4.40
自引率
0.00%
发文量
73
期刊介绍: This newest addition to the Clinics Series keeps you current on the information that is essential to every practicing surgical pathologist, from the latest techniques and approaches to detailed discussions on differential diagnosis. It devotes each and every issue exclusively to surgical pathology and its associated problems and is enhanced by abundant full-color images. Each issue focuses on a single topic-and is overseen by Guest Editors who are experts in their field-providing information of practical value on service while also offering material that increases understanding.
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