微重力对免疫状态的影响。

Q3 Medicine ImmunoHorizons Pub Date : 2023-10-01 DOI:10.4049/immunohorizons.2200063
Janelle Hicks, Makaila Olson, Carol Mitchell, Cassandra M Juran, Amber M Paul
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引用次数: 0

摘要

当我们探索其他行星体时,宇航员将面临独特的环境和生理挑战。人类的免疫系统是在地球引力的作用下进化而来的。因此,在太空的微重力环境中,免疫功能发生了改变。这可能会给执行深空任务的宇航员带来问题性后果,因为在深空任务中,医疗干预将受到限制。研究微重力的独特环境有其挑战,但目前的研究已经发现了探索任务中可能出现的免疫状态。随着微重力诱导的免疫状态的发现,可以设计新的对策开发和个性化的缓解计划来改善宇航员的健康。这也有利于地球上疾病的免疫相关监测项目。这是对人类和啮齿动物模型中模拟和太空微重力研究的全面综述,包括知识空白。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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The Impact of Microgravity on Immunological States.

As we explore other planetary bodies, astronauts will face unique environmental and physiological challenges. The human immune system has evolved under Earth's gravitational force. Consequently, in the microgravity environment of space, immune function is altered. This can pose problematic consequences for astronauts on deep space missions where medical intervention will be limited. Studying the unique environment of microgravity has its challenges, yet current research has uncovered immunological states that are probable during exploration missions. As microgravity-induced immune states are uncovered, novel countermeasure developments and personalized mitigation programs can be designed to improve astronaut health. This can also benefit immune-related monitoring programs for disorders on Earth. This is a comprehensive review, including gaps in knowledge, of simulated and spaceflight microgravity studies in human and rodent models.

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CiteScore
3.70
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