pT1结直肠癌癌症:治疗难题。

IF 3.2 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Best Practice & Research Clinical Gastroenterology Pub Date : 2023-10-01 DOI:10.1016/j.bpg.2023.101854
Angelo Brunori , Maria Daca-Alvarez , Maria Pellisé
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引用次数: 0

摘要

癌症(CRC)人群筛查计划的实施导致源自可接受局部治疗的息肉的pT1-CRC患病率显著增加。然而,很高比例的患者被转诊进行不必要的肿瘤手术,但在生存方面没有明显的益处。在诊断时选择合适的内镜切除技术对于为每个息肉和患者提供最佳治疗方案至关重要。为此,必须提高鉴别pT1-CRC的光学诊断技能,并决定合适的初始治疗方法。整体切除对于获得足够的组织学标本至关重要,这可能允许保留器官的治疗管理。在这篇综述中,我们解决了T1 CRC管理中的关键挑战,探索了现有诊断和治疗方法的有效性和安全性,并阐明了该领域即将取得的进展。
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pT1 colorectal cancer: A treatment dilemma

The implementation of population screening programs for colorectal cancer (CRC) has led to a considerable increase in the prevalence pT1-CRC originating on polyps amenable by local treatments. However, a high proportion of patients are referred for unnecessary oncological surgeries without a clear benefit in terms of survival. Selecting the appropriate endoscopic resection technique in the moment of diagnosis becomes crucial to provide the best treatment alternative to each individual polyp and patient. For this, it is imperative to increase the optical diagnostic skill for differentiating pT1-CRCs and decide the appropriate initial therapy. En bloc resection is crucial to obtain an adequate histological specimen that might allow organ preserving therapeutic management. In this review, we address key challenges in T1 CRC management, explore the efficacy and safety of the available diagnostic and therapeutic approaches, and shed light on upcoming advances in the field.

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来源期刊
CiteScore
5.50
自引率
0.00%
发文量
23
审稿时长
69 days
期刊介绍: Each topic-based issue of Best Practice & Research Clinical Gastroenterology will provide a comprehensive review of current clinical practice and thinking within the specialty of gastroenterology.
期刊最新文献
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