M. Elliott Williams , Felica P. Hardnett , Anandi N. Sheth , Alexander N. Wein , Zheng-Rong Tiger Li , Jessica Radzio-Basu , Chuong Dinh , Lisa B. Haddad , Elizabeth M.B. Collins , Igho Ofotokun , Rustom Antia , Christopher D. Scharer , J. Gerardo Garcia-Lerma , Jacob E. Kohlmeier , Alison Swaims-Kohlmeier
{"title":"月经周期通过CCR5信号调节女性生殖道中CD4 T细胞迁移监测。","authors":"M. Elliott Williams , Felica P. Hardnett , Anandi N. Sheth , Alexander N. Wein , Zheng-Rong Tiger Li , Jessica Radzio-Basu , Chuong Dinh , Lisa B. Haddad , Elizabeth M.B. Collins , Igho Ofotokun , Rustom Antia , Christopher D. Scharer , J. Gerardo Garcia-Lerma , Jacob E. Kohlmeier , Alison Swaims-Kohlmeier","doi":"10.1016/j.mucimm.2023.10.002","DOIUrl":null,"url":null,"abstract":"<div><p>Despite their importance for immunity against sexually transmitted infections, the composition of female reproductive tract (FRT) memory T-cell populations in response to changes within the local tissue environment under the regulation of the menstrual cycle remains poorly defined. Here, we show that in humans and pig-tailed macaques, the cycle determines distinct clusters of differentiation 4 T-cell surveillance behaviors by subsets corresponding to migratory memory (T<sub>MM</sub>) and resident memory T cells. T<sub>MM</sub> displays tissue-itinerant trafficking characteristics, restricted distribution within the FRT microenvironment, and distinct effector responses to infection. Gene pathway analysis by RNA sequencing identified T<sub>MM</sub>-specific enrichment of genes involved in hormonal regulation and inflammatory responses. FRT T-cell subset fluctuations were discovered that synchronized to cycle-driven CCR5 signaling. Notably, oral administration of a CCR5 antagonist drug blocked T<sub>MM</sub> trafficking. Taken together, this study provides novel insights into the dynamic nature of FRT memory CD4 T cells and identifies the menstrual cycle as a key regulator of immune surveillance at the site of STI pathogen exposure.</p></div>","PeriodicalId":18877,"journal":{"name":"Mucosal Immunology","volume":"17 1","pages":"Pages 41-53"},"PeriodicalIF":7.9000,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1933021923000806/pdfft?md5=d405ae138fb8dd79fd34fde6046024ca&pid=1-s2.0-S1933021923000806-main.pdf","citationCount":"0","resultStr":"{\"title\":\"The menstrual cycle regulates migratory CD4 T-cell surveillance in the female reproductive tract via CCR5 signaling\",\"authors\":\"M. Elliott Williams , Felica P. Hardnett , Anandi N. Sheth , Alexander N. Wein , Zheng-Rong Tiger Li , Jessica Radzio-Basu , Chuong Dinh , Lisa B. Haddad , Elizabeth M.B. Collins , Igho Ofotokun , Rustom Antia , Christopher D. Scharer , J. Gerardo Garcia-Lerma , Jacob E. Kohlmeier , Alison Swaims-Kohlmeier\",\"doi\":\"10.1016/j.mucimm.2023.10.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Despite their importance for immunity against sexually transmitted infections, the composition of female reproductive tract (FRT) memory T-cell populations in response to changes within the local tissue environment under the regulation of the menstrual cycle remains poorly defined. Here, we show that in humans and pig-tailed macaques, the cycle determines distinct clusters of differentiation 4 T-cell surveillance behaviors by subsets corresponding to migratory memory (T<sub>MM</sub>) and resident memory T cells. T<sub>MM</sub> displays tissue-itinerant trafficking characteristics, restricted distribution within the FRT microenvironment, and distinct effector responses to infection. Gene pathway analysis by RNA sequencing identified T<sub>MM</sub>-specific enrichment of genes involved in hormonal regulation and inflammatory responses. FRT T-cell subset fluctuations were discovered that synchronized to cycle-driven CCR5 signaling. Notably, oral administration of a CCR5 antagonist drug blocked T<sub>MM</sub> trafficking. Taken together, this study provides novel insights into the dynamic nature of FRT memory CD4 T cells and identifies the menstrual cycle as a key regulator of immune surveillance at the site of STI pathogen exposure.</p></div>\",\"PeriodicalId\":18877,\"journal\":{\"name\":\"Mucosal Immunology\",\"volume\":\"17 1\",\"pages\":\"Pages 41-53\"},\"PeriodicalIF\":7.9000,\"publicationDate\":\"2024-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S1933021923000806/pdfft?md5=d405ae138fb8dd79fd34fde6046024ca&pid=1-s2.0-S1933021923000806-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Mucosal Immunology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1933021923000806\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"IMMUNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Mucosal Immunology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1933021923000806","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
The menstrual cycle regulates migratory CD4 T-cell surveillance in the female reproductive tract via CCR5 signaling
Despite their importance for immunity against sexually transmitted infections, the composition of female reproductive tract (FRT) memory T-cell populations in response to changes within the local tissue environment under the regulation of the menstrual cycle remains poorly defined. Here, we show that in humans and pig-tailed macaques, the cycle determines distinct clusters of differentiation 4 T-cell surveillance behaviors by subsets corresponding to migratory memory (TMM) and resident memory T cells. TMM displays tissue-itinerant trafficking characteristics, restricted distribution within the FRT microenvironment, and distinct effector responses to infection. Gene pathway analysis by RNA sequencing identified TMM-specific enrichment of genes involved in hormonal regulation and inflammatory responses. FRT T-cell subset fluctuations were discovered that synchronized to cycle-driven CCR5 signaling. Notably, oral administration of a CCR5 antagonist drug blocked TMM trafficking. Taken together, this study provides novel insights into the dynamic nature of FRT memory CD4 T cells and identifies the menstrual cycle as a key regulator of immune surveillance at the site of STI pathogen exposure.
期刊介绍:
Mucosal Immunology, the official publication of the Society of Mucosal Immunology (SMI), serves as a forum for both basic and clinical scientists to discuss immunity and inflammation involving mucosal tissues. It covers gastrointestinal, pulmonary, nasopharyngeal, oral, ocular, and genitourinary immunology through original research articles, scholarly reviews, commentaries, editorials, and letters. The journal gives equal consideration to basic, translational, and clinical studies and also serves as a primary communication channel for the SMI governing board and its members, featuring society news, meeting announcements, policy discussions, and job/training opportunities advertisements.