补片方向、缺损位置和尺寸对疝补片生物力学相容性的影响

IF 5.6 4区 医学 Q1 ENGINEERING, BIOMEDICAL Irbm Pub Date : 2023-08-01 DOI:10.1016/j.irbm.2023.100777
Wei He , Fei Shen , Zhiwei Xu , Baoqing Pei , Huiqi Xie , Xiaoming Li
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引用次数: 0

摘要

目的种植体良好的生物力学相容性对于获得所需的组织修复效率至关重要。在这里,我们通过计算模拟和动物实验研究了网格方向、缺陷位置和尺寸三个重要影响因素对典型各向异性网格生物力学兼容性的综合影响。方法根据CT图像和单轴试验获得的材料本构模型建立兔的数值模型,研究两个方向、两个缺陷位置和两个缺陷尺寸。对兔子进行了相应的气腹试验,并对腹壁表面的位移进行了无创测量以进行验证。结果数值结果表明,当网状物的最硬方向与头尾方向平行时,腹壁的位移受到限制,但缝合区的应力大大降低。当缺陷位于不同肌肉的交界处时,应变分布变得不均匀。此外,对于尺寸较小的缺陷,不同网格方向引起的结果之间的差异较小。动物实验结果与数值结果吻合较好。对假设网格方向的进一步模拟表明,对于所有四种不同的缺陷,当网格的最硬方向与斜肌的方向一致时,网格表现出更好的生物力学兼容性。结论网状物的取向是影响缺损组织各向异性的主要因素,网状物的正确取向与缺损组织的各向异性不一定一致。此外,对于不同组织交界处的缺陷,应考虑具有不对称刚度的网格设计。最后,在修复小缺陷时,可以将网状物的最硬方向与缺陷组织的方向对齐,以实现更好的顺应性。我们的发现可以为高性能各向异性网格的开发及其在外科手术中的适当选择和放置提供一些可靠和有指导意义的指导。本研究提出的方法可用于全面、指导性地评估疝环网片的生物力学相容性,预测其修复效果,并在投入临床使用前确定其合适的位置。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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The Effect of Mesh Orientation, Defect Location and Size on the Biomechanical Compatibility of Hernia Mesh

Objectives

Satisfactory biomechanical compatibility of implants is important for obtaining desired tissue repair efficiency. Here, we investigated the combined effects of three important influencing factors, mesh orientation, defect location and size, on biomechanical compatibility of a typical anisotropic mesh by both computational simulation and animal experiment.

Methods

Numerical models of rabbits were developed based on CT images and material constitutive models obtained by uniaxial tests, during which two orientations, two defect locations and two defect sizes were investigated. Corresponding pneumoperitoneum tests on rabbits and non-invasive measurements on the displacement of abdominal wall surface were performed for validation.

Results

Numerical results showed that the displacement of abdominal wall was limited when the stiffest direction of mesh was parallel to the cranio-caudal direction, but the stress in suture area was greatly reduced. When the defect was located at the junction of different muscles, the strain distribution became uneven. In addition, for the defects with smaller size, difference between the results caused by different mesh orientations was smaller. Animal experimental results were in good agreement with the numerical results. Further simulations for a hypothetical mesh orientation showed that the meshes exhibited better biomechanical compatibility when their stiffest direction was consistent with that of oblique muscles for all four different defects.

Conclusion

The mesh orientation was the most influential factor and the proper orientation of the mesh was not necessarily consistent with the anisotropy of the defect tissue. In addition, the mesh design with asymmetric stiffness should be considered for defects at the junction of different tissues. Finally, it is possible to align the stiffest direction of the mesh with that of the defect tissue in repairing small defects to achieve better compliance. Our findings could provide some reliable and instructive guidelines for high-performance anisotropic meshes development and their appropriate selection and placement in surgery. And methods proposed in this study could be used to comprehensively and instructively evaluate the biomechanical compatibility of hernia meshes, predict their repair effect, and determine their appropriate positioning before they are put into clinical use.

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来源期刊
Irbm
Irbm ENGINEERING, BIOMEDICAL-
CiteScore
10.30
自引率
4.20%
发文量
81
审稿时长
57 days
期刊介绍: IRBM is the journal of the AGBM (Alliance for engineering in Biology an Medicine / Alliance pour le génie biologique et médical) and the SFGBM (BioMedical Engineering French Society / Société française de génie biologique médical) and the AFIB (French Association of Biomedical Engineers / Association française des ingénieurs biomédicaux). As a vehicle of information and knowledge in the field of biomedical technologies, IRBM is devoted to fundamental as well as clinical research. Biomedical engineering and use of new technologies are the cornerstones of IRBM, providing authors and users with the latest information. Its six issues per year propose reviews (state-of-the-art and current knowledge), original articles directed at fundamental research and articles focusing on biomedical engineering. All articles are submitted to peer reviewers acting as guarantors for IRBM''s scientific and medical content. The field covered by IRBM includes all the discipline of Biomedical engineering. Thereby, the type of papers published include those that cover the technological and methodological development in: -Physiological and Biological Signal processing (EEG, MEG, ECG…)- Medical Image processing- Biomechanics- Biomaterials- Medical Physics- Biophysics- Physiological and Biological Sensors- Information technologies in healthcare- Disability research- Computational physiology- …
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