[(PNP)Mn(CO)2]与有机磷酸盐的反应性

IF 3.3 Q2 CHEMISTRY, MULTIDISCIPLINARY ACS Organic & Inorganic Au Pub Date : 2023-05-25 DOI:10.1021/acsorginorgau.3c00003
Brooke N. Livesay, Jurgen G. Schmidt, Robert F. Williams, Brennan S. Billow* and Aaron M. Tondreau*, 
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引用次数: 0

摘要

有机磷神经毒剂是一类有毒的合成化合物,会对许多生物系统产生不良影响。环境修复和钝化方法的开发已经进行了多年。然而,在暴露受害者的治疗开发方面进展甚微。考虑到OPA材料在乙酰胆碱酯酶(AChE)等酶中的暴露后行为,开发亲电化合物作为治疗剂可能比目前使用的亲核对策更有益。在本报告中,我们介绍了我们对亲电的16电子锰络合物(iPrPNP)Mn(CO)2(1)和亲核的氢氧化物衍生物(iPrNHP)Mn。研究了1与磷酸的反应性和2与氟磷酸二异丙酯(DIPF)的P–F键的反应性。用17O标记的水研究了水在亲核和亲电反应中的作用。报道了1和2与有机磷底物反应产生的有希望的结果。
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Reactivity of [(PNP)Mn(CO)2] with Organophosphates

Organophosphorus nerve agents (OPAs) are a toxic class of synthetic compounds that cause adverse effects with many biological systems. Development of methods for environmental remediation and passivation has been ongoing for years. However, little progress has been made in therapeutic development for exposure victims. Given the postexposure behavior of OPA materials in enzymes such as acetylcholinesterase (AChE), development of electrophilic compounds as therapeutics may be more beneficial than the currently employed nucleophilic countermeasures. In this report, we present our studies with an electrophilic, 16-electron manganese complex (iPrPNP)Mn(CO)2 (1) and the nucleophilic hydroxide derivative (iPrPNHP)Mn(CO)2(OH) (2). The reactivity of 1 with phosphorus acids and the reactivity of 2 with the P–F bond of diisopropylfluorophosphate (DIPF) were studied. The role of water in both nucleophilic and electrophilic reactivity was investigated with the use of 17O-labeled water. Promising results arising from reactions of both 1 and 2 with organophosphorus substrates are reported.

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来源期刊
ACS Organic & Inorganic Au
ACS Organic & Inorganic Au 有机化学、无机化学-
CiteScore
4.10
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0.00%
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期刊介绍: ACS Organic & Inorganic Au is an open access journal that publishes original experimental and theoretical/computational studies on organic organometallic inorganic crystal growth and engineering and organic process chemistry. Short letters comprehensive articles reviews and perspectives are welcome on topics that include:Organic chemistry Organometallic chemistry Inorganic Chemistry and Organic Process Chemistry.
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