{"title":"用于医学生物绘图应用的优化PCL/CNF生物纳米复合材料:流变、结构和热机械方面","authors":"Nectarios Vidakis , Markos Petousis , Nikolaos Michailidis , Constantine David , Nikolaos Mountakis , Vassilis Papadakis , Evangelos Sfakiotakis , Dimitrios Sagris , Mariza Spiridaki , Apostolos Argyros","doi":"10.1016/j.bprint.2023.e00311","DOIUrl":null,"url":null,"abstract":"<div><p><span><span><span><span>The use of bioabsorbable and biodegradable composites in the medical field has experienced significant growth. Cellulose<span> nanofibers (CNF) have been employed to reinforce medical-grade poly[ε-caprolactone], enhancing both its load-bearing capacity and stiffness compared to pure polycaprolactone PCL. The </span></span>manufacturing process<span> involved a series of steps applied to five different grades of PCL/CNF filaments. Initially, melt extrusion and </span></span>pelletization were performed on the filament, followed by 3D bioplotting to create the specimens. The influence of CNF reinforcement on poly[ε-caprolactone] was evaluated through a range of tests, including rheological, thermomechanical, and in situ micromechanical assessments. To further characterize the samples, Micro-Computed </span>Tomography<span> and Scanning Electron Microscopy fractography were employed for the microstructural and morphological analyses, respectively. The </span></span>mechanical properties<span> of poly[ε-caprolactone]/CNF composites with 6 wt % CNF content exhibited a 23.8% increase in tensile strength<span> and a 19.1% increase in flexural strength compared to the pure matrix, while also displaying minimal porosity.</span></span></p></div>","PeriodicalId":37770,"journal":{"name":"Bioprinting","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Optimized PCL/CNF bio-nanocomposites for medical bio-plotted applications: Rheological, structural, and thermomechanical aspects\",\"authors\":\"Nectarios Vidakis , Markos Petousis , Nikolaos Michailidis , Constantine David , Nikolaos Mountakis , Vassilis Papadakis , Evangelos Sfakiotakis , Dimitrios Sagris , Mariza Spiridaki , Apostolos Argyros\",\"doi\":\"10.1016/j.bprint.2023.e00311\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span><span><span><span>The use of bioabsorbable and biodegradable composites in the medical field has experienced significant growth. Cellulose<span> nanofibers (CNF) have been employed to reinforce medical-grade poly[ε-caprolactone], enhancing both its load-bearing capacity and stiffness compared to pure polycaprolactone PCL. The </span></span>manufacturing process<span> involved a series of steps applied to five different grades of PCL/CNF filaments. Initially, melt extrusion and </span></span>pelletization were performed on the filament, followed by 3D bioplotting to create the specimens. The influence of CNF reinforcement on poly[ε-caprolactone] was evaluated through a range of tests, including rheological, thermomechanical, and in situ micromechanical assessments. To further characterize the samples, Micro-Computed </span>Tomography<span> and Scanning Electron Microscopy fractography were employed for the microstructural and morphological analyses, respectively. The </span></span>mechanical properties<span> of poly[ε-caprolactone]/CNF composites with 6 wt % CNF content exhibited a 23.8% increase in tensile strength<span> and a 19.1% increase in flexural strength compared to the pure matrix, while also displaying minimal porosity.</span></span></p></div>\",\"PeriodicalId\":37770,\"journal\":{\"name\":\"Bioprinting\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-09-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Bioprinting\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2405886623000544\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"Computer Science\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bioprinting","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2405886623000544","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Computer Science","Score":null,"Total":0}
Optimized PCL/CNF bio-nanocomposites for medical bio-plotted applications: Rheological, structural, and thermomechanical aspects
The use of bioabsorbable and biodegradable composites in the medical field has experienced significant growth. Cellulose nanofibers (CNF) have been employed to reinforce medical-grade poly[ε-caprolactone], enhancing both its load-bearing capacity and stiffness compared to pure polycaprolactone PCL. The manufacturing process involved a series of steps applied to five different grades of PCL/CNF filaments. Initially, melt extrusion and pelletization were performed on the filament, followed by 3D bioplotting to create the specimens. The influence of CNF reinforcement on poly[ε-caprolactone] was evaluated through a range of tests, including rheological, thermomechanical, and in situ micromechanical assessments. To further characterize the samples, Micro-Computed Tomography and Scanning Electron Microscopy fractography were employed for the microstructural and morphological analyses, respectively. The mechanical properties of poly[ε-caprolactone]/CNF composites with 6 wt % CNF content exhibited a 23.8% increase in tensile strength and a 19.1% increase in flexural strength compared to the pure matrix, while also displaying minimal porosity.
期刊介绍:
Bioprinting is a broad-spectrum, multidisciplinary journal that covers all aspects of 3D fabrication technology involving biological tissues, organs and cells for medical and biotechnology applications. Topics covered include nanomaterials, biomaterials, scaffolds, 3D printing technology, imaging and CAD/CAM software and hardware, post-printing bioreactor maturation, cell and biological factor patterning, biofabrication, tissue engineering and other applications of 3D bioprinting technology. Bioprinting publishes research reports describing novel results with high clinical significance in all areas of 3D bioprinting research. Bioprinting issues contain a wide variety of review and analysis articles covering topics relevant to 3D bioprinting ranging from basic biological, material and technical advances to pre-clinical and clinical applications of 3D bioprinting.