Linfoma difuso de células B grandes primario de cérvix. A propósito de un caso

Introduction

Primary involvement of the female genital tract by non-Hodgkin lymphoma is very rare, so there is no consensus on treatment, and for this reason we present this clinical case and the treatment performed, as well as the prognosis of our patient.

Clinical findings

The patient presented is a 72-year-old woman who consulted for vaginal bleeding.

Diagnosis

Primary extranodal non-Hodgkin lymphoma of the cervix with immunophenotype B of high cytological grade and high proliferative index was diagnosed.

Therapeutic interventions and results

The treatment of choice was chemotherapy only. This patient has presented a disease-free survival of 5 years. It is currently being monitored by carrying out annual analytical controls.

Conclusion

The symptoms of this type of tumor are highly non-specific, as well as cytology is frequently negative, which is why it is necessary to resort to biopsy. Immunohistochemistry is essential for both diagnosis and prognosis. There are multiple imaging techniques used for both extension study and follow-up, highlighting the role of FDG-PET.

It currently seems that the most recommendable treatment is the R-CHOP chemotherapy regimen followed by radiotherapy.

The prognosis is generally good, with up to 80% survival at 5 years.