{"title":"严重子痫前期和原发性甲状腺功能减退患者的母体和胎儿结果。病例和对照研究","authors":"J.G. Vázquez Rodríguez , C.E. Penagos Chanona , J.G. Vázquez Arredondo","doi":"10.1016/j.gine.2023.100846","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><p>Primary hypothyroidism has adverse effects on maternal and fetal outcomes. In the scenario of severe preeclampsia (SP), the impact on the binomial may be greater.</p></div><div><h3>Objective</h3><p>To compare maternal and fetal outcomes in patients with SP and primary hypothyroidism.</p></div><div><h3>Material and methods</h3><p>This was a case-control study in 58 pregnant patients with SP admitted to the Intensive Care Unit of a High Specialty Unit in Mexico City attended from January 2018 to December 2021. The case group was formed with 29 patients with pre-pregnancy primary hypothyroidism and the control group with 29 age-matched patients with normal pre-pregnancy thyroid function. Their overall data and maternal and fetal outcomes were compared. Descriptive statistics, chi-square test, and Student's t-test with the SPSS version 20 programme were used. A p-value<<!--> <!-->0.05 was significant.</p></div><div><h3>Results</h3><p>No differences were found in age (p<!--> <!-->=<!--> <!-->.8292), parity (p<!--> <!-->=<!--> <!-->1), systolic (p<!--> <!-->=<!--> <!-->.7229) and diastolic (p<!--> <!-->=<!--> <!-->.5498) blood pressure, caesarean section (p<!--> <!-->=<!--> <!-->.812), intrapartum haemorrhage (p<!--> <!-->=<!--> <!-->.812), p<!--> <!-->=<!--> <!-->.3558), anaesthetic technique (p<!--> <!-->=<!--> <!-->.5786), obstetric complications, Intensive Care Unit stay (p<!--> <!-->=<!--> <!-->.6181), and mortality. There were no differences in the products: singleton pregnancy (p<!--> <!-->=<!--> <!-->.912), gestational age (p<!--> <!-->=<!--> <!-->.8901), weight (p<!--> <!-->=<!--> <!-->.3338), Apgar score minute one and five, prematurity (p<!--> <!-->=<!--> <!-->.8701), intensive care (p<!--> <!-->=<!--> <!-->.0623), in utero mortality (n<!--> <!-->=<!--> <!-->4 vs n<!--> <!-->=<!--> <!-->4), and mortality at birth (n<!--> <!-->=<!--> <!-->2 vs n<!--> <!-->=<!--> <!-->0).</p></div><div><h3>Conclusions</h3><p>Maternal and fetal outcomes were similar. The cases with uncontrolled thyroid did not show adverse clinical effects.</p></div>","PeriodicalId":41294,"journal":{"name":"Clinica e Investigacion en Ginecologia y Obstetricia","volume":null,"pages":null},"PeriodicalIF":0.1000,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Resultados maternos y fetales en pacientes con preeclampsia severa e hipotiroidismo primario. Estudio de casos y controles\",\"authors\":\"J.G. Vázquez Rodríguez , C.E. Penagos Chanona , J.G. Vázquez Arredondo\",\"doi\":\"10.1016/j.gine.2023.100846\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction</h3><p>Primary hypothyroidism has adverse effects on maternal and fetal outcomes. In the scenario of severe preeclampsia (SP), the impact on the binomial may be greater.</p></div><div><h3>Objective</h3><p>To compare maternal and fetal outcomes in patients with SP and primary hypothyroidism.</p></div><div><h3>Material and methods</h3><p>This was a case-control study in 58 pregnant patients with SP admitted to the Intensive Care Unit of a High Specialty Unit in Mexico City attended from January 2018 to December 2021. The case group was formed with 29 patients with pre-pregnancy primary hypothyroidism and the control group with 29 age-matched patients with normal pre-pregnancy thyroid function. Their overall data and maternal and fetal outcomes were compared. Descriptive statistics, chi-square test, and Student's t-test with the SPSS version 20 programme were used. A p-value<<!--> <!-->0.05 was significant.</p></div><div><h3>Results</h3><p>No differences were found in age (p<!--> <!-->=<!--> <!-->.8292), parity (p<!--> <!-->=<!--> <!-->1), systolic (p<!--> <!-->=<!--> <!-->.7229) and diastolic (p<!--> <!-->=<!--> <!-->.5498) blood pressure, caesarean section (p<!--> <!-->=<!--> <!-->.812), intrapartum haemorrhage (p<!--> <!-->=<!--> <!-->.812), p<!--> <!-->=<!--> <!-->.3558), anaesthetic technique (p<!--> <!-->=<!--> <!-->.5786), obstetric complications, Intensive Care Unit stay (p<!--> <!-->=<!--> <!-->.6181), and mortality. There were no differences in the products: singleton pregnancy (p<!--> <!-->=<!--> <!-->.912), gestational age (p<!--> <!-->=<!--> <!-->.8901), weight (p<!--> <!-->=<!--> <!-->.3338), Apgar score minute one and five, prematurity (p<!--> <!-->=<!--> <!-->.8701), intensive care (p<!--> <!-->=<!--> <!-->.0623), in utero mortality (n<!--> <!-->=<!--> <!-->4 vs n<!--> <!-->=<!--> <!-->4), and mortality at birth (n<!--> <!-->=<!--> <!-->2 vs n<!--> <!-->=<!--> <!-->0).</p></div><div><h3>Conclusions</h3><p>Maternal and fetal outcomes were similar. 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引用次数: 0
摘要
原发性甲状腺功能减退症对母婴结局有不良影响。在严重子痫前期(SP)的情况下,对二项的影响可能更大。目的比较SP与原发性甲状腺功能减退患者的母胎结局。材料和方法本研究是一项病例对照研究,纳入了2018年1月至2021年12月在墨西哥城一家高级专科病房重症监护病房就诊的58名妊娠SP患者。病例组29例为孕前原发性甲状腺功能减退症患者,对照组29例为孕前甲状腺功能正常、年龄匹配的患者。比较她们的总体数据和母婴结局。采用SPSS version 20程序进行描述性统计、卡方检验和学生t检验。p-value<0.05差异有统计学意义。结果年龄(p = 0.8292)、胎次(p = 1)、收缩压(p = 0.7229)、舒张压(p = 0.5498)、剖宫产(p = 0.812)、产时出血(p = 0.812)、产时出血(p = 0.3558)、麻醉技术(p = 0.5786)、产科并发症、重症监护病房住院时间(p = 0.6181)、死亡率等方面无差异。单胎妊娠(p = 0.912)、胎龄(p = 0.8901)、体重(p = 0.3338)、Apgar评分第1分钟和第5分钟、早产(p = 0.8701)、重症监护(p = 0.0623)、子宫内死亡率(n = 4 vs n = 4)、出生时死亡率(n = 2 vs n = 0)。结论母胎结局相似。甲状腺不控制的病例未出现不良临床反应。
Resultados maternos y fetales en pacientes con preeclampsia severa e hipotiroidismo primario. Estudio de casos y controles
Introduction
Primary hypothyroidism has adverse effects on maternal and fetal outcomes. In the scenario of severe preeclampsia (SP), the impact on the binomial may be greater.
Objective
To compare maternal and fetal outcomes in patients with SP and primary hypothyroidism.
Material and methods
This was a case-control study in 58 pregnant patients with SP admitted to the Intensive Care Unit of a High Specialty Unit in Mexico City attended from January 2018 to December 2021. The case group was formed with 29 patients with pre-pregnancy primary hypothyroidism and the control group with 29 age-matched patients with normal pre-pregnancy thyroid function. Their overall data and maternal and fetal outcomes were compared. Descriptive statistics, chi-square test, and Student's t-test with the SPSS version 20 programme were used. A p-value< 0.05 was significant.
Results
No differences were found in age (p = .8292), parity (p = 1), systolic (p = .7229) and diastolic (p = .5498) blood pressure, caesarean section (p = .812), intrapartum haemorrhage (p = .812), p = .3558), anaesthetic technique (p = .5786), obstetric complications, Intensive Care Unit stay (p = .6181), and mortality. There were no differences in the products: singleton pregnancy (p = .912), gestational age (p = .8901), weight (p = .3338), Apgar score minute one and five, prematurity (p = .8701), intensive care (p = .0623), in utero mortality (n = 4 vs n = 4), and mortality at birth (n = 2 vs n = 0).
Conclusions
Maternal and fetal outcomes were similar. The cases with uncontrolled thyroid did not show adverse clinical effects.
期刊介绍:
Una excelente publicación para mantenerse al día en los temas de máximo interés de la ginecología de vanguardia. Resulta idónea tanto para el especialista en ginecología, como en obstetricia o en pediatría, y está presente en los más prestigiosos índices de referencia en medicina.