狼疮性肾炎的转录组研究

IF 2.9 4区 医学 Q3 IMMUNOLOGY Archivum Immunologiae et Therapiae Experimentalis Pub Date : 2022-04-25 DOI:10.1007/s00005-022-00651-y
Marta E. Alarcón-Riquelme
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引用次数: 0

摘要

本综述旨在描述利用基因表达分析狼疮性肾炎患者肾组织样本的主要工作。大多数研究都使用了基因表达阵列,这极大地提高了我们对狼疮性肾炎可能机制的认识。然而,使用大量基因表达平台,无论是作为阵列还是作为RNA测序,都不足以深入了解细胞及其分子模式和单细胞疾病机制的细节。最近,发表了第一项单细胞RNA测序研究,这也将在狼疮性肾炎的背景下进行讨论。单细胞RNA测序可以检索感兴趣组织或血液中每个细胞中表达的基因。在这种情况下,这些研究的结果让我们第一次看到了狼疮性肾炎肾脏的样子,但要了解狼疮性肾炎的治疗或不同病理亚型及其细胞含量的变化,还有很多工作要做。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Transcriptome Studies in Lupus Nephritis

The present review is aimed at describing the main works that have used gene expression to analyze tissue kidney samples of lupus nephritis patients. Most studies used the gene expression arrays, which enormously advanced our knowledge on the possible mechanisms behind lupus nephritis. However, using bulk gene expression platforms, either as arrays, or as sequencing of RNA is not enough to go into detail of the cells and their molecular patterns and single cell mechanisms of disease. More recently, the first single cell RNA Sequencing study was published and this will also be discussed in the context of lupus nephritis. Single cell RNA sequencing allows to retrieve the genes expressed in each cell in the tissue of interest or in blood. In this context, the results of such studies give us a first glimpse of how a lupus nephritis kidney looks like, but much is still to be done to understand the changes that occur with treatment or with the different pathological subtypes of lupus nephritis and their cellular content.

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来源期刊
CiteScore
5.90
自引率
0.00%
发文量
26
审稿时长
>12 weeks
期刊介绍: Archivum Immunologiae et Therapiae Experimentalis (AITE), founded in 1953 by Ludwik Hirszfeld, is a bimonthly, multidisciplinary journal. It publishes reviews and full original papers dealing with immunology, experimental therapy, immunogenetics, transplantation, microbiology, immunochemistry and ethics in science.
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