BRCA1高表达是LUAD的独立预后生物标志物,与免疫浸润相关

Cancer Innovation Pub Date : 2023-04-13 DOI:10.1002/cai2.65
Fengzhu Guo, Cong Li, Shuning Liu, Zhijun Li, Jingtong Zhai, Zhiwu Wang, Binghe Xu
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引用次数: 0

摘要

与BRCA1水平降低的患者相比,乳腺癌症易感性基因1(BRCA1)表达升高的肺腺癌(LUAD)患者的总生存率和无进展生存率明显较差。相反,BRCA1的表达与鳞状细胞癌患者的生存结果无关。BRCA1的过度表达是LUAD的一个独立风险因素,表明肿瘤微环境具有免疫抑制作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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High BRCA1 expression is an independent prognostic biomarker in LUAD and correlates with immune infiltration

Lung adenocarcinoma (LUAD) patients with elevated breast cancer susceptibility gene 1 (BRCA1) expression had markedly worse overall survival and progression-free survival compared to those with reduced BRCA1 levels. In contrast, BRCA1 expression did not correlate with survival outcomes in squamous cell carcinoma patients. The overexpression of BRCA1 was an independent risk factor for LUAD and was indicative of an immune-suppressive tumor microenvironment.

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