探测单个生物分子的研究进展:从DNA碱基到聚糖

IF 24.5 Q1 CHEMISTRY, PHYSICAL Interdisciplinary Materials Pub Date : 2023-06-25 DOI:10.1002/idm2.12106
Baofei Hou, Teng Zhang, Huixia Yang, Xu Han, Liwei Liu, Linfei Li, Cesare Grazioli, Xu Wu, Nan Jiang, Yeliang Wang
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引用次数: 2

摘要

在真实空间中对生物分子进行成像对于在最基本的层面上全面了解生物系统的性质和功能至关重要。在可用于生物分子及其组装的纳米结构的各种成像技术中,扫描探针显微镜(SPM)提供了一种强大且无损的成像选择。SPM在纳米尺度上可视化本质无序的生物分子(例如聚糖)方面是独特的。这篇综述强调了使用SPM技术研究生物分子的最新成就,重点是DNA碱基、氨基酸、蛋白质和聚糖。SPM使生物分子的原子级分析成为可能,从而可以更准确地定义局部结构-性质关系。单个生物分子的高分辨率SPM成像为在分子水平上研究生命的基本过程提供了一种新的方法。
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Advances in probing single biomolecules: From DNA bases to glycans

Imaging biomolecules in real space is crucial for gaining a comprehensive understanding of the properties and functions of biological systems at the most fundamental level. Among the various imaging techniques available for biomolecules and their assembled nanostructures, scanning probe microscopy (SPM) provides a powerful and nondestructive imaging option. SPM is unique in visualizing intrinsically disordered biomolecules at the nanometer scale (e.g., glycans). This review highlights recent achievements in studying biomolecules using SPM technique, focusing on DNA bases, amino acids, proteins, and glycans. The atomic-level analysis of biomolecules made possible by SPM allows for a more accurate definition of the local structure–property relationship. High-resolution SPM imaging of single biomolecules offers a new way to study basic processes of life at the molecular level.

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