颅脑损伤后骨愈合的机制

Brain-X Pub Date : 2023-09-28 DOI:10.1002/brx2.31
Yuan Xiong, Wenbin Zhong, Bobin Mi
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引用次数: 0

摘要

越来越多的证据表明,与孤立骨折的患者相比,经历创伤性脑损伤的患者表现出明显更短的愈合期。然而,这一现象背后的确切潜在机制尚不清楚。最近的研究揭示了源自下丘脑的激素信号和神经回路的潜在作用,它们在调节骨骼系统中发挥着至关重要的作用。尽管取得了这些进展,但缺乏全面的研究来总结骨愈合在创伤性脑损伤中的关键作用及其潜在机制。这篇综述旨在探索在TBI患者中观察到的加速骨愈合的潜在机制,特别关注TBI和骨重塑之间复杂的串扰。此外,我们全面讨论和总结了TBI对骨骼系统的有益作用,并研究了TBI诱导的导致骨折愈合和骨重塑加速的信号通路。通过剖析这些途径,我们旨在确定干预和促进骨修复的潜在靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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The mechanism of bone healing after traumatic brain injury

A growing body of evidence suggests that patients who experience traumatic brain injuries (TBIs) exhibit significantly shorter healing periods compared to those with isolated fractures. However, the precise underlying mechanism behind this phenomenon remains unclear. Recent studies have shed light on the potential role of hormonal signals and neural circuits originating in the hypothalamus, which play vital roles in regulating the skeletal system. Despite these advances, there is a lack of comprehensive research summarizing the crucial role of bone healing in TBIs and the underlying mechanisms. This review aimed to explore the underlying mechanisms responsible for the accelerated bone healing observed in TBI patients, with a specific focus on the intricate crosstalk between TBI and bone remodeling. Additionally, we comprehensively discuss and summarize the beneficial effects of TBI on the skeletal system and examine the TBI-induced signaling pathways that result in accelerated fracture healing and bone remodeling. By dissecting these pathways, we aim to identify potential targets for intervention and bone repair promotion.

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