Gopika Sivan, Divya P Sukumaran, Akhil Prakash Ezhuthanikkunnel, Mohamed Hatha Ammanamveetil Abdulla
{"title":"喀拉拉邦城市化红树林生态系统水和沉积物中大肠杆菌对β-内酰胺酶抗性和CTX-M 1组基因的扩展谱患病率。","authors":"Gopika Sivan, Divya P Sukumaran, Akhil Prakash Ezhuthanikkunnel, Mohamed Hatha Ammanamveetil Abdulla","doi":"10.1089/mdr.2023.0089","DOIUrl":null,"url":null,"abstract":"<p><p>The study aimed to determine the prevalence of extended-spectrum β-lactamase resistance and CTX-M-group 1 gene in <i>Escherichia coli</i> from the water and sediment of three urbanized mangrove ecosystems of Kerala. A total of 119 <i>E. coli</i> isolates were screened for antibiotic susceptibility to 16 antibiotics. According to the phylogenetic analysis of <i>E. coli</i> isolates, nonpathogenic group A and pathogenic group D (29.4% and 23.5%) were the predominant phylotypes found in water samples. The most frequent phylotypes found in sediment samples were nonpathogenic groups A and B1 (27.9% and 26.4%). The highest incidence of antibiotic resistance in <i>E. coli</i> was against cefotaxime and colistin (100%). A significant difference in the prevalence of CTX-M-group 1 gene was observed among <i>E. coli</i> isolates in water samples (<i>p</i> < 0.05). The results indicate a high prevalence of β-lactamase harboring <i>E. coli</i> in the mangrove ecosystems that can hamper mangrove-dependent aquaculture practices and human health.</p>","PeriodicalId":18701,"journal":{"name":"Microbial drug resistance","volume":" ","pages":"582-588"},"PeriodicalIF":2.3000,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Prevalence of Extended-Spectrum Beta-Lactamase Resistance and CTX-M-Group 1 Gene in <i>Escherichia coli</i> from the Water and Sediment of Urbanized Mangrove Ecosystems of Kerala.\",\"authors\":\"Gopika Sivan, Divya P Sukumaran, Akhil Prakash Ezhuthanikkunnel, Mohamed Hatha Ammanamveetil Abdulla\",\"doi\":\"10.1089/mdr.2023.0089\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The study aimed to determine the prevalence of extended-spectrum β-lactamase resistance and CTX-M-group 1 gene in <i>Escherichia coli</i> from the water and sediment of three urbanized mangrove ecosystems of Kerala. A total of 119 <i>E. coli</i> isolates were screened for antibiotic susceptibility to 16 antibiotics. According to the phylogenetic analysis of <i>E. coli</i> isolates, nonpathogenic group A and pathogenic group D (29.4% and 23.5%) were the predominant phylotypes found in water samples. The most frequent phylotypes found in sediment samples were nonpathogenic groups A and B1 (27.9% and 26.4%). The highest incidence of antibiotic resistance in <i>E. coli</i> was against cefotaxime and colistin (100%). A significant difference in the prevalence of CTX-M-group 1 gene was observed among <i>E. coli</i> isolates in water samples (<i>p</i> < 0.05). The results indicate a high prevalence of β-lactamase harboring <i>E. coli</i> in the mangrove ecosystems that can hamper mangrove-dependent aquaculture practices and human health.</p>\",\"PeriodicalId\":18701,\"journal\":{\"name\":\"Microbial drug resistance\",\"volume\":\" \",\"pages\":\"582-588\"},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2023-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Microbial drug resistance\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1089/mdr.2023.0089\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/10/26 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Microbial drug resistance","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1089/mdr.2023.0089","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/10/26 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
Prevalence of Extended-Spectrum Beta-Lactamase Resistance and CTX-M-Group 1 Gene in Escherichia coli from the Water and Sediment of Urbanized Mangrove Ecosystems of Kerala.
The study aimed to determine the prevalence of extended-spectrum β-lactamase resistance and CTX-M-group 1 gene in Escherichia coli from the water and sediment of three urbanized mangrove ecosystems of Kerala. A total of 119 E. coli isolates were screened for antibiotic susceptibility to 16 antibiotics. According to the phylogenetic analysis of E. coli isolates, nonpathogenic group A and pathogenic group D (29.4% and 23.5%) were the predominant phylotypes found in water samples. The most frequent phylotypes found in sediment samples were nonpathogenic groups A and B1 (27.9% and 26.4%). The highest incidence of antibiotic resistance in E. coli was against cefotaxime and colistin (100%). A significant difference in the prevalence of CTX-M-group 1 gene was observed among E. coli isolates in water samples (p < 0.05). The results indicate a high prevalence of β-lactamase harboring E. coli in the mangrove ecosystems that can hamper mangrove-dependent aquaculture practices and human health.
期刊介绍：
Microbial Drug Resistance (MDR) is an international, peer-reviewed journal that covers the global spread and threat of multi-drug resistant clones of major pathogens that are widely documented in hospitals and the scientific community. The Journal addresses the serious challenges of trying to decipher the molecular mechanisms of drug resistance. MDR provides a multidisciplinary forum for peer-reviewed original publications as well as topical reviews and special reports.
MDR coverage includes:
Molecular biology of resistance mechanisms
Virulence genes and disease
Molecular epidemiology
Drug design
Infection control.
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