Masashi Ishida , Aya Yamamura , Moe Fujiwara , Taiki Amano , Mina Ota , Yukari Hikawa , Rubii Kondo , Yoshiaki Suzuki , Yuji Imaizumi , Hisao Yamamura
{"title":"Pimaric acid通过激活BKCa通道和抑制VDCC降低大鼠肺动脉平滑肌的血管收缩","authors":"Masashi Ishida , Aya Yamamura , Moe Fujiwara , Taiki Amano , Mina Ota , Yukari Hikawa , Rubii Kondo , Yoshiaki Suzuki , Yuji Imaizumi , Hisao Yamamura","doi":"10.1016/j.jphs.2023.08.001","DOIUrl":null,"url":null,"abstract":"<div><p>Pulmonary vessels play a pivotal role in oxygen circulation. We previously demonstrated that pimaric acid (PiMA) activated large-conductance Ca<sup>2+</sup>-activated K<sup>+</sup> (BK<sub>Ca</sub>) channels and inhibited voltage-dependent Ca<sup>2+</sup> channels (VDCCs). In the present study, PiMA attenuated vasoconstriction induced by high K<sup>+</sup> or endothelin-1 in rat pulmonary arterial smooth muscles (PASMs). PiMA also reduced high K<sup>+</sup>-induced cytosolic [Ca<sup>2+</sup>] increase in PASM cells. PiMA increased BK<sub>Ca</sub> currents and decreased VDCC currents. BK<sub>Ca</sub> channels and VDCCs were formed by the α/β<sub>1</sub> and α<sub>1C</sub>/α<sub>1D</sub>/β<sub>2</sub>/β<sub>3</sub> subunits, respectively. These results indicate that PiMA induces vasorelaxation through the dual effects of BK<sub>Ca</sub> channel activation and VDCC inhibition in PASMs.</p></div>","PeriodicalId":16786,"journal":{"name":"Journal of pharmacological sciences","volume":"153 2","pages":"Pages 84-88"},"PeriodicalIF":3.0000,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Pimaric acid reduces vasoconstriction via BKCa channel activation and VDCC inhibition in rat pulmonary arterial smooth muscles\",\"authors\":\"Masashi Ishida , Aya Yamamura , Moe Fujiwara , Taiki Amano , Mina Ota , Yukari Hikawa , Rubii Kondo , Yoshiaki Suzuki , Yuji Imaizumi , Hisao Yamamura\",\"doi\":\"10.1016/j.jphs.2023.08.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Pulmonary vessels play a pivotal role in oxygen circulation. We previously demonstrated that pimaric acid (PiMA) activated large-conductance Ca<sup>2+</sup>-activated K<sup>+</sup> (BK<sub>Ca</sub>) channels and inhibited voltage-dependent Ca<sup>2+</sup> channels (VDCCs). In the present study, PiMA attenuated vasoconstriction induced by high K<sup>+</sup> or endothelin-1 in rat pulmonary arterial smooth muscles (PASMs). PiMA also reduced high K<sup>+</sup>-induced cytosolic [Ca<sup>2+</sup>] increase in PASM cells. PiMA increased BK<sub>Ca</sub> currents and decreased VDCC currents. BK<sub>Ca</sub> channels and VDCCs were formed by the α/β<sub>1</sub> and α<sub>1C</sub>/α<sub>1D</sub>/β<sub>2</sub>/β<sub>3</sub> subunits, respectively. These results indicate that PiMA induces vasorelaxation through the dual effects of BK<sub>Ca</sub> channel activation and VDCC inhibition in PASMs.</p></div>\",\"PeriodicalId\":16786,\"journal\":{\"name\":\"Journal of pharmacological sciences\",\"volume\":\"153 2\",\"pages\":\"Pages 84-88\"},\"PeriodicalIF\":3.0000,\"publicationDate\":\"2023-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of pharmacological sciences\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1347861323000452\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of pharmacological sciences","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1347861323000452","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
Pimaric acid reduces vasoconstriction via BKCa channel activation and VDCC inhibition in rat pulmonary arterial smooth muscles
Pulmonary vessels play a pivotal role in oxygen circulation. We previously demonstrated that pimaric acid (PiMA) activated large-conductance Ca2+-activated K+ (BKCa) channels and inhibited voltage-dependent Ca2+ channels (VDCCs). In the present study, PiMA attenuated vasoconstriction induced by high K+ or endothelin-1 in rat pulmonary arterial smooth muscles (PASMs). PiMA also reduced high K+-induced cytosolic [Ca2+] increase in PASM cells. PiMA increased BKCa currents and decreased VDCC currents. BKCa channels and VDCCs were formed by the α/β1 and α1C/α1D/β2/β3 subunits, respectively. These results indicate that PiMA induces vasorelaxation through the dual effects of BKCa channel activation and VDCC inhibition in PASMs.
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Journal of Pharmacological Sciences (JPS) is an international open access journal intended for the advancement of pharmacological sciences in the world. The Journal welcomes submissions in all fields of experimental and clinical pharmacology, including neuroscience, and biochemical, cellular, and molecular pharmacology for publication as Reviews, Full Papers or Short Communications. Short Communications are short research article intended to provide novel and exciting pharmacological findings. Manuscripts concerning descriptive case reports, pharmacokinetic and pharmacodynamic studies without pharmacological mechanism and dose-response determinations are not acceptable and will be rejected without peer review. The ethnopharmacological studies are also out of the scope of this journal. Furthermore, JPS does not publish work on the actions of biological extracts unknown chemical composition.
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