糖化血红蛋白与灰质体积和抑郁的关系:探讨灰质体积的中介作用

Q1 Social Sciences Global Transitions Pub Date : 2023-01-01 DOI:10.1016/j.glt.2023.06.004
Dashan Zheng , Miao Cai , Zhengmin (Min) Qian , Chongjian Wang , Shiyu Zhang , Zilong Zhang , Xiaojie Wang , Michael G. Vaughn , Elizabeth Bingheim , Hualiang Lin
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引用次数: 1

摘要

背景抑郁症给全世界的人类带来了巨大的健康负担。低血糖已被发现是抑郁症的一个重要危险因素。然而,这种关系的生物学机制在很大程度上仍然未知。方法该分析来自英国生物库的33151名参与者,他们提供了2014年至2020年的脑磁共振成像数据。参与者被分为糖尿病组、糖尿病前期组和非糖尿病组,以及年龄≥60岁和<;60年。基于多变量线性和逻辑回归,我们评估了117个脑区的糖化血红蛋白(HbA1c)、灰质体积(GMV)与抑郁症之间的关系。我们进一步研究了GMV对HbA1c与抑郁症关系的中介作用。结果HbA1c升高与GMV降低和抑郁有关。观察到较低的GMV与抑郁症有关。此外,与糖尿病前期和非糖尿病患者相比,糖尿病前期患者的相关性最强,且年龄≥60岁的患者的相关性更大。我们进一步观察到GMV对HbA1c与抑郁之间的关系具有显著的中介作用,HbA1c抑郁标志区介导的作用比例为7.29%(95%CI:1.43%,34.38%)。在全球老龄化的背景下,不健康的血糖会对人群造成更严重的脑损伤,有效控制老年人的血糖水平会对大脑健康产生积极影响,并可能降低患抑郁症的风险。
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The associations of glycosylated hemoglobin with grey matter volume and depression: Investigating mediating role of grey matter volume

Background

Depression has caused enormous health burden to human worldwide. Glycemia has been found as one important risk factor of depression. However, the biological mechanism underlying this relationship remained largely unknown.

Methods

This analysis was derived from a cohort of 33,151 participants in the UK Biobank who provided brain magnetic resonance imaging data from 2014 to 2020. Participants were classified into diabetic, prediabetic and non-diabetic groups, as well as groups aged ≥60 years and <60 years. We assessed the associations between glycosylated hemoglobin (HbA1c), grey matter volume (GMV) in 117 brain regions, and depression based on the multivariable linear and logistic regression. We further investigated the mediation effect of GMV on the relationship between HbA1c and depression.

Results

Higher HbA1c was found to be associated with reduced GMV and depression. Lower GMV was observed associated with depression. Moreover, the association was strongest in prediabetes compared to prediabetic and non-diabetic, and the association was greater in those aged ≥60 years. We further observed a significant mediation effect of GMV on the association between HbA1c and depression, and the proportions of the effect mediated by HbA1c-depression signatured regions was 7.29% (95% CI: 1.43%, 34.38%).

Conclusions

This study suggests that HbA1c is associated with cerebral grey matter abnormality especially in participants aged ≥60 years. In the context of global aging, the unhealthy blood sugar can contribute to more severe brain damage for the population and effective control of blood sugar levels among the elderly can have a positive impact on brain health and potentially reduce the risk of developing depression.

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来源期刊
Global Transitions
Global Transitions Social Sciences-Development
CiteScore
18.90
自引率
0.00%
发文量
1
审稿时长
20 weeks
期刊最新文献
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