Data Sources and Computational Approaches for Generating Models of Gene Regulatory Networks

OUTLINE Introduction Formal representation of GRNs An example of a GRN: The Lac Operon Hierarchies of GRN models: From probabilistic graphs to mechanistic models A guide to databases and knowledgebases on the internet Pathway Databases & Platforms Ontologies for GRN modeling Current Gene, Interaction, and Pathway Ontologies Whole­cell modeling platforms Ontology for modeling multi­scale and incomplete networks An ontology for cellular processes The PATIKA pathway ontology Extracting Models from Pathways Databases Pathway and Dynamic Analysis Tools for GRNs Global network properties Recurring network motifs Identifying pathway channels in networks: extreme pathway analysis Network stability analysis 3 Predicting dynamics & bistability from network structure alone