{"title":"降解抑制底物的连续搅拌槽生物反应器的操作范围","authors":"Cleophas L.C. Migiro, Wo̵dzimierz Sokół","doi":"10.1016/0300-9467(92)80007-W","DOIUrl":null,"url":null,"abstract":"<div><p>An analysis of various models of a continuous stirred-tank bioreactor (CSTB) showed that those based on the specific uptake rate of substrate described the dynamics of the CSTB satisfactorily for controlling the parameters after a disturbance so that all substrate introduced into the bioreactor was utilized.</p><p>The maximum values of dilution rate <em>D</em><sub>max</sub> and/or substrate concentration S<sub>0 max</sub> in the feed after a step increase in <em>D</em> and/or <em>S</em><sub>0</sub> respectively which could be achieved without causing cell washout were measured and compared with those calculated using a “short-cut” method. It was found that the calculated values of <em>D</em><sub>max</sub> and <em>S</em> <sub>0 max</sub> were lower by approximately 20% than the experimental results. Thus the values of <em>D</em><sub>max</sub> and <em>S</em><sub>0 max</sub> predicted by the short-cut method were not substantial underestimates and can be considered safe for the operation of a CSTB utilizing inhibitory substrates.</p></div>","PeriodicalId":101225,"journal":{"name":"The Chemical Engineering Journal","volume":"50 1","pages":"Pages B1-B7"},"PeriodicalIF":0.0000,"publicationDate":"1992-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0300-9467(92)80007-W","citationCount":"6","resultStr":"{\"title\":\"Operational range for a continuous stirred-tank bioreactor degrading an inhibitory substrate\",\"authors\":\"Cleophas L.C. Migiro, Wo̵dzimierz Sokół\",\"doi\":\"10.1016/0300-9467(92)80007-W\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>An analysis of various models of a continuous stirred-tank bioreactor (CSTB) showed that those based on the specific uptake rate of substrate described the dynamics of the CSTB satisfactorily for controlling the parameters after a disturbance so that all substrate introduced into the bioreactor was utilized.</p><p>The maximum values of dilution rate <em>D</em><sub>max</sub> and/or substrate concentration S<sub>0 max</sub> in the feed after a step increase in <em>D</em> and/or <em>S</em><sub>0</sub> respectively which could be achieved without causing cell washout were measured and compared with those calculated using a “short-cut” method. It was found that the calculated values of <em>D</em><sub>max</sub> and <em>S</em> <sub>0 max</sub> were lower by approximately 20% than the experimental results. Thus the values of <em>D</em><sub>max</sub> and <em>S</em><sub>0 max</sub> predicted by the short-cut method were not substantial underestimates and can be considered safe for the operation of a CSTB utilizing inhibitory substrates.</p></div>\",\"PeriodicalId\":101225,\"journal\":{\"name\":\"The Chemical Engineering Journal\",\"volume\":\"50 1\",\"pages\":\"Pages B1-B7\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1992-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0300-9467(92)80007-W\",\"citationCount\":\"6\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Chemical Engineering Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/030094679280007W\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Chemical Engineering Journal","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/030094679280007W","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Operational range for a continuous stirred-tank bioreactor degrading an inhibitory substrate
An analysis of various models of a continuous stirred-tank bioreactor (CSTB) showed that those based on the specific uptake rate of substrate described the dynamics of the CSTB satisfactorily for controlling the parameters after a disturbance so that all substrate introduced into the bioreactor was utilized.
The maximum values of dilution rate Dmax and/or substrate concentration S0 max in the feed after a step increase in D and/or S0 respectively which could be achieved without causing cell washout were measured and compared with those calculated using a “short-cut” method. It was found that the calculated values of Dmax and S0 max were lower by approximately 20% than the experimental results. Thus the values of Dmax and S0 max predicted by the short-cut method were not substantial underestimates and can be considered safe for the operation of a CSTB utilizing inhibitory substrates.
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