十年腹主动脉瘤治疗-血管内排除vs开放手术在葡萄牙不同地区

Ricardo Castro‐Ferreira , Manuel Neiva‐Sousa , Sérgio Sampaio , Paulo Gonçalves Dias , Altamiro da Costa‐Pereira , Alberto Freitas
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引用次数: 5

摘要

背景腹主动脉瘤(AAA)影响大约5%的65岁以上男性,估计是西方国家第十大死亡原因。对于较大的AAA患者,可以选择开放性修复(OR)或血管内动脉瘤修复(EVAR)进行手术,以防止破裂,这是AAA的主要并发症。据我们所知,葡萄牙大陆国立医院从未进行过一项详细的研究,比较AAA修复的治疗选择及其相关的住院死亡率。目的本分析的目的是确定i)每个地区国立医院送交修复的动脉瘤类型的比例,ii)其中每种手术治疗的比例,iii)与每种治疗相关的院内死亡率。方法所有在2000 - 2010年间接受or或EVAR治疗的被诊断为破裂或未破裂AAAs的患者,其信息可在住院医院管理数据库中获得。该数据库包含来自葡萄牙大陆所有公立医院的数据。为了评估这些数据的区域时间演变,对2000年至2010年期间进行了年度表征。评估每个国家地区的AAA类型、矫正方式的选择和住院死亡率。结果2000年至2010年,葡萄牙大陆共登记了3101例AAAs维修。未破裂AAAs的发生率是破裂AAAs的3倍(75% vs. 25%)。区域比较显示,北部和里斯本地区未破裂AAA/破裂AAA的比例明显高于中部地区。在评估的11年中,AAA破裂的频率保持相当稳定。在所有地区,无论是破裂还是未破裂的AAAs, OR都是首选的治疗方法。然而,从2005年到2010年,EVAR的选择一直在增加,实际上在2010年期间成为北部和里斯本最常用的方法(这两个地区占55%)。所有评估地区的AAAs破裂死亡率相似(北部52%,中部52%,里斯本51%)。在AAA破裂的修复中,EVAR和OR之间没有显著差异(OR的住院死亡率为51%,而EVAR的住院死亡率为52%)。在北部和里斯本的州立医院,EVAR修复非破裂AAA的效果显著改善(北部为2.1%对6,6%,里斯本为5.5%对8,7%,p <0 05)。在Centro的州立医院中没有观察到差异。结论葡萄牙大陆公立医院每年的AAA修复数量在所有地区都在增加,其中EVAR修复一直很突出。与OR相比,在北部和里斯本的州立医院,当用于非破裂AAA修复的选择性手术时,EVAR呈现出更有利的住院死亡率结果。
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Dez anos de tratamento de aneurismas da aorta abdominal – exclusão endovascular vs. cirurgia aberta nas diferentes regiões portuguesas

Background

Abdominal aortic aneurysms (AAA) affect approximately 5% of men over 65 years of age and are estimated to be the tenth leading cause of mortality in Western countries. Elective surgery either by open repair (OR) or endovascular aneurysm repair (EVAR) is indicated in patients with large AAAs, preventing rupture, the major complication of AAA. To the best of our knowledge a detailed study comparing the treatment choice for AAA repair as well as its associated in‐hospital mortality in Portuguese mainland state hospitals has never been performed.

Aim

The purpose of this analysis was to determine i) the proportion of aneurysm type submitted to repair in each region state hospitals, ii) the proportion of each type of surgical treatment among them, iii) the in‐hospital mortality associated with each treatment.

Methods

All individuals diagnosed with ruptured or non‐ruptured AAAs submitted to either OR or EVAR between 2000 and 2010, whose information was available on an inpatient hospital administrative database, were selected for the study. The database contained data from all Portuguese mainland state hospitals. To evaluate the regional chronological evolution of these data, a yearly characterization for the period between 2000 and 2010 was performed. The type of AAA, its choice of correction and the in‐hospital mortality were evaluated for each national region.

Results

Between the years 2000 and 2010, 3101 AAAs repairs were registered in mainland Portugal. Non‐ruptured AAAs were three times more frequent than ruptured AAAs (75% vs. 25%). Regional comparison showed the non‐ruptured AAA/ruptured AAA ratio in Norte and Lisboa to be significantly higher than that in Centro. Ruptured AAA frequency remained fairly stable during the 11 years evaluated. OR was the preferred method for treatment of both ruptured and non‐ruptured AAAs in all regions. Nevertheless, the choice for EVAR has been increasing from the period of 2005 to 2010, actually becoming the most frequent method in Norte and Lisboa during 2010 (55% in both regions). Ruptured AAAs mortality was similar in all the evaluated regions (52% in Norte, 52% in Centro and 51% in Lisboa). No significant differences were found between EVAR and OR in the repair of ruptured AAA (in‐hospital mortality of 51% in OR vs. 52% in EVAR). A significant improved outcome was obtained with EVAR in the repair of non‐ruptured AAA in state hospitals of Norte and Lisboa (2,1% vs. 6,6% in Norte and 5,0% vs. 8,7% in Lisboa, p < 0,05). No differences were observed in state hospitals of Centro.

Conclusions

The yearly number of AAA repairs in Portuguese mainland state hospitals is increasing across all regions, with EVAR repair consistently gaining prominence. Compared to OR, EVAR presents a more favourable in‐hospital mortality outcome in state hospitals of Norte and Lisboa, when used in elective surgeries for non‐ruptured AAA repairs.

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