{"title":"BRD4下调可抑制宫颈癌细胞活力，但不影响病毒癌蛋白的表达","authors":"Veronica Canarte , Karl Munger","doi":"10.1016/j.crviro.2021.100010","DOIUrl":null,"url":null,"abstract":"<div><p>Human papillomavirus (HPV) expressing cervical cancer lines are sensitized to inhibition of the Bromodomain Containing 4 (BRD4) epigenetic reader protein and this has been linked to decreased expression of the viral E6 and E7 oncoproteins from the viral promoter. Here we show that BRD4 depletion can inhibit the viability of HPV16-positive cervical carcinoma cells and HPV16 E6/E7 expressing cells through a mechanism that is independent of affecting viral oncoprotein expression.</p></div>","PeriodicalId":72755,"journal":{"name":"Current research in virological science","volume":"2 ","pages":"Article 100010"},"PeriodicalIF":0.0000,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.crviro.2021.100010","citationCount":"1","resultStr":"{\"title\":\"BRD4 downregulation inhibits the viability of cervical cancer cells without affecting viral oncoprotein expression\",\"authors\":\"Veronica Canarte , Karl Munger\",\"doi\":\"10.1016/j.crviro.2021.100010\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Human papillomavirus (HPV) expressing cervical cancer lines are sensitized to inhibition of the Bromodomain Containing 4 (BRD4) epigenetic reader protein and this has been linked to decreased expression of the viral E6 and E7 oncoproteins from the viral promoter. Here we show that BRD4 depletion can inhibit the viability of HPV16-positive cervical carcinoma cells and HPV16 E6/E7 expressing cells through a mechanism that is independent of affecting viral oncoprotein expression.</p></div>\",\"PeriodicalId\":72755,\"journal\":{\"name\":\"Current research in virological science\",\"volume\":\"2 \",\"pages\":\"Article 100010\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.crviro.2021.100010\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current research in virological science\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2666478X21000040\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current research in virological science","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666478X21000040","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
BRD4 downregulation inhibits the viability of cervical cancer cells without affecting viral oncoprotein expression
Human papillomavirus (HPV) expressing cervical cancer lines are sensitized to inhibition of the Bromodomain Containing 4 (BRD4) epigenetic reader protein and this has been linked to decreased expression of the viral E6 and E7 oncoproteins from the viral promoter. Here we show that BRD4 depletion can inhibit the viability of HPV16-positive cervical carcinoma cells and HPV16 E6/E7 expressing cells through a mechanism that is independent of affecting viral oncoprotein expression.
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