Linn Antberg , Paolo Cifani , Fredrik Levander , Peter James
{"title":"两种乳腺细胞系对化疗药物的DNA损伤反应的通路中心分析","authors":"Linn Antberg , Paolo Cifani , Fredrik Levander , Peter James","doi":"10.1016/j.euprot.2015.05.002","DOIUrl":null,"url":null,"abstract":"<div><p>The response to DNA damage by alkylation and DNA topoisomerase inhibition was studied in two breast cancer cells lines. We present data from both a shotgun and a targeted, pathway-centric approach to highlight the different DNA repair pathway modulation in the cell lines and the correlation with viability and DNA damage assays. This type of focussed profiling may be of utility in rapidly defining non-responders undergoing systemic neoadjuvant therapy.</p></div>","PeriodicalId":38260,"journal":{"name":"EuPA Open Proteomics","volume":"8 ","pages":"Pages 128-136"},"PeriodicalIF":0.0000,"publicationDate":"2015-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.euprot.2015.05.002","citationCount":"6","resultStr":"{\"title\":\"Pathway-centric analysis of the DNA damage response to chemotherapeutic agents in two breast cell lines\",\"authors\":\"Linn Antberg , Paolo Cifani , Fredrik Levander , Peter James\",\"doi\":\"10.1016/j.euprot.2015.05.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The response to DNA damage by alkylation and DNA topoisomerase inhibition was studied in two breast cancer cells lines. We present data from both a shotgun and a targeted, pathway-centric approach to highlight the different DNA repair pathway modulation in the cell lines and the correlation with viability and DNA damage assays. This type of focussed profiling may be of utility in rapidly defining non-responders undergoing systemic neoadjuvant therapy.</p></div>\",\"PeriodicalId\":38260,\"journal\":{\"name\":\"EuPA Open Proteomics\",\"volume\":\"8 \",\"pages\":\"Pages 128-136\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2015-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.euprot.2015.05.002\",\"citationCount\":\"6\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"EuPA Open Proteomics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2212968515000148\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Biochemistry, Genetics and Molecular Biology\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"EuPA Open Proteomics","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2212968515000148","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
Pathway-centric analysis of the DNA damage response to chemotherapeutic agents in two breast cell lines
The response to DNA damage by alkylation and DNA topoisomerase inhibition was studied in two breast cancer cells lines. We present data from both a shotgun and a targeted, pathway-centric approach to highlight the different DNA repair pathway modulation in the cell lines and the correlation with viability and DNA damage assays. This type of focussed profiling may be of utility in rapidly defining non-responders undergoing systemic neoadjuvant therapy.
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