A. Ferella, D.Bellido, P. Chacana, A. Wigdorovitz, M.J. Dus Santos, M.V. Mozgovoj
{"title":"鸡卵黄抗牛呼吸道合胞病毒抗体可在体外中和该病毒。","authors":"A. Ferella, D.Bellido, P. Chacana, A. Wigdorovitz, M.J. Dus Santos, M.V. Mozgovoj","doi":"10.1016/j.provac.2012.04.006","DOIUrl":null,"url":null,"abstract":"<div><p>Bovine respiratory syncytial virus (BRSV) and its counterpart in humans (HRSV) are two closely related virus, which are the leading cause of severe respiratory syndrome in calves and young children, respectively. Passive immunization can be a practical alternative to conventional vaccination in order to prevent the disease. In this report the production of chicken egg yolk IgY and its ability to neutralize BRSV <em>in vitro</em> were assessed. Purified IgY against BRSV specifically recognized BRSV in a dot blot assay and was able to neutralize the virus in a viral neutralization assay. These results demonstrate the potential use of IgY as a prophylactic treatment against RSV infection.</p></div>","PeriodicalId":89221,"journal":{"name":"Procedia in vaccinology","volume":"6 ","pages":"Pages 33-38"},"PeriodicalIF":0.0000,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.provac.2012.04.006","citationCount":"14","resultStr":"{\"title\":\"Chicken egg yolk antibodies against bovine respiratory syncytial virus neutralize the virus in vitro.\",\"authors\":\"A. Ferella, D.Bellido, P. Chacana, A. Wigdorovitz, M.J. Dus Santos, M.V. Mozgovoj\",\"doi\":\"10.1016/j.provac.2012.04.006\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Bovine respiratory syncytial virus (BRSV) and its counterpart in humans (HRSV) are two closely related virus, which are the leading cause of severe respiratory syndrome in calves and young children, respectively. Passive immunization can be a practical alternative to conventional vaccination in order to prevent the disease. In this report the production of chicken egg yolk IgY and its ability to neutralize BRSV <em>in vitro</em> were assessed. Purified IgY against BRSV specifically recognized BRSV in a dot blot assay and was able to neutralize the virus in a viral neutralization assay. These results demonstrate the potential use of IgY as a prophylactic treatment against RSV infection.</p></div>\",\"PeriodicalId\":89221,\"journal\":{\"name\":\"Procedia in vaccinology\",\"volume\":\"6 \",\"pages\":\"Pages 33-38\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2012-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.provac.2012.04.006\",\"citationCount\":\"14\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Procedia in vaccinology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1877282X12000082\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Procedia in vaccinology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1877282X12000082","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Chicken egg yolk antibodies against bovine respiratory syncytial virus neutralize the virus in vitro.
Bovine respiratory syncytial virus (BRSV) and its counterpart in humans (HRSV) are two closely related virus, which are the leading cause of severe respiratory syndrome in calves and young children, respectively. Passive immunization can be a practical alternative to conventional vaccination in order to prevent the disease. In this report the production of chicken egg yolk IgY and its ability to neutralize BRSV in vitro were assessed. Purified IgY against BRSV specifically recognized BRSV in a dot blot assay and was able to neutralize the virus in a viral neutralization assay. These results demonstrate the potential use of IgY as a prophylactic treatment against RSV infection.
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