J. Ben Arous , F. Bertrand , J. Gaucheron , O.A. Verkhovsky , A.P. Kotelnikov , E.V. Shemelkov , K.P. Alekseev , L. Dupuis
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引用次数: 3
摘要
猪圆环病毒相关病(PCVADs)是由猪圆环病毒2型(PCV2)引起的家猪重要的经济疾病。PCV2疫苗接种通常使用佐剂灭活配方进行，对于控制猪场PCVADs和与PCV2相关的亚临床体重损失是必要的。PCV2疫苗制剂的一个重要问题是PCV2抗原介质通常具有使疫苗制剂不稳定的特性。疫苗佐剂是现代疫苗接种的关键参数，与疫苗配方的galenic特性密切相关，而galenic稳定性是确保疫苗保质期内疗效稳定的必要条件。在这里，我们展示了基于MontanideTM ISA 11R VG(水中油)和MontanideTM ESSAI Gel R(聚合物)佐剂的特别设计的配方能够抵抗非常不稳定的抗原介质和条件，同时保持安全参数和功效在要求的水平。
Adjuvant Formulations Designed to Improve Swine Vaccine Stability: Application to PCV2 Vaccines
Porcine circovirus associated diseases (PCVADs) are economically important diseases of domestic pigs caused by porcine circovirus type 2 (PCV2). PCV2 vaccination is usually performed with adjuvanted inactivated formulations and is necessary to control PCVADs and subclinical PCV2 related body weight losses in pig farming. An important issue with PCV2 vaccine formulation is that PCV2 antigenic media often have properties which destabilize vaccine formulations. Vaccine adjuvants are a key parameter in modern vaccination closely linked to galenic properties of vaccine formulations, and galenic stability is necessary to insure efficacy stability during vaccine shelf life. Here we show that especially designed formulations based on MontanideTM ISA 11R VG (Oil in water) and MontanideTM ESSAI Gel R (polymer) adjuvants are able to resist to very destabilizing antigenic media and conditions while keeping safety parameters and efficacy at requested levels.
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