{"title":"β-内酰胺类抗生素，β-内酰胺酶与细菌耐药性","authors":"L.P. Kotra, S. Mobashery","doi":"10.1016/S0020-2452(98)80009-2","DOIUrl":null,"url":null,"abstract":"<div><p>β-Lactams are the most prescribed antibacterials for the treatment of bacterial infections. Bacteria have developed mechanisms to resist the action of β-lactam drugs, of which the catalytic function of β-lactamase is the most important. These enzymes catalyse hydrolysis of β-lactam antibiotics, whereby the drug is destroyed. This review offers a perspective on the function of these enzymes and their clinical implications.</p></div>","PeriodicalId":89103,"journal":{"name":"Bulletin de l'Institut Pasteur","volume":"96 3","pages":"Pages 139-150"},"PeriodicalIF":0.0000,"publicationDate":"1998-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0020-2452(98)80009-2","citationCount":"51","resultStr":"{\"title\":\"β-Lactam antibiotics, β-lactamases and bacterial resistance\",\"authors\":\"L.P. Kotra, S. Mobashery\",\"doi\":\"10.1016/S0020-2452(98)80009-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>β-Lactams are the most prescribed antibacterials for the treatment of bacterial infections. Bacteria have developed mechanisms to resist the action of β-lactam drugs, of which the catalytic function of β-lactamase is the most important. These enzymes catalyse hydrolysis of β-lactam antibiotics, whereby the drug is destroyed. This review offers a perspective on the function of these enzymes and their clinical implications.</p></div>\",\"PeriodicalId\":89103,\"journal\":{\"name\":\"Bulletin de l'Institut Pasteur\",\"volume\":\"96 3\",\"pages\":\"Pages 139-150\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1998-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S0020-2452(98)80009-2\",\"citationCount\":\"51\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Bulletin de l'Institut Pasteur\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0020245298800092\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bulletin de l'Institut Pasteur","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0020245298800092","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
β-Lactam antibiotics, β-lactamases and bacterial resistance
β-Lactams are the most prescribed antibacterials for the treatment of bacterial infections. Bacteria have developed mechanisms to resist the action of β-lactam drugs, of which the catalytic function of β-lactamase is the most important. These enzymes catalyse hydrolysis of β-lactam antibiotics, whereby the drug is destroyed. This review offers a perspective on the function of these enzymes and their clinical implications.
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