回想起来,“荷兰DNA修复小组”

Dirk Bootsma
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引用次数: 7

摘要

“荷兰DNA修复小组”成立于35年前。在这个简短的历史回顾中,描述了一些重要的决定,这些决定有助于这一群体的研究取得相对成功。本小组多年来的工作重点是核苷酸切除修复(NER)的遗传分析和基于该修复过程缺陷的遗传性疾病:着色性干皮病(XP), Cockayne综合征和毛硫营养不良。
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The “Dutch DNA Repair Group”, in retrospect

The “Dutch DNA Repair Group” was established about 35 years ago. In this brief historical review some of the crucial decisions are described that have contributed to the relative success of the research of this group. The emphasis of the work of this group has been for many years on the genetic analysis of nucleotide excision repair (NER) and genetic diseases based on defects in this repair process: xeroderma pigmentosum (XP), Cockayne syndrome and trichothiodystrophy.

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S. cerevisiae has three pathways for DNA interstrand crosslink repair Molecular characterization of ionizing radiation-hypersensitive mutant M10 cells Backbone dynamics of DNA containing 8-oxoguanine: importance for substrate recognition by base excision repair glycosylases Relationship between base excision repair capacity and DNA alkylating agent sensitivity in mouse monocytes Disruption of Xpg increases spontaneous mutation frequency, particularly A:T to C:G transversion
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