{"title":"5-甲酰基尿嘧啶在DNA中的细胞效应","authors":"Svein Bjelland , Hilde Ånensen , Ingeborg Knævelsrud , Erling Seeberg","doi":"10.1016/S0921-8777(01)00085-4","DOIUrl":null,"url":null,"abstract":"<div><p><span>5-Formyluracil is a major oxidation product of </span>thymine, formed in DNA in yields comparable to that of 8-oxo-7,8-dihydroguanine by exposure to γ-irradiation. Whereas the repair pathways for removal and the biological effects of persisting 8-oxo-7,8-dihydroguanine are much elucidated, much less attention has been paid to the cellular implications of 5-formyluracil in DNA. Here we review the present state of knowledge in this important area within research on oxidative DNA damage.</p></div>","PeriodicalId":100935,"journal":{"name":"Mutation Research/DNA Repair","volume":"486 2","pages":"Pages 147-154"},"PeriodicalIF":0.0000,"publicationDate":"2001-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0921-8777(01)00085-4","citationCount":"29","resultStr":"{\"title\":\"Cellular effects of 5-formyluracil in DNA\",\"authors\":\"Svein Bjelland , Hilde Ånensen , Ingeborg Knævelsrud , Erling Seeberg\",\"doi\":\"10.1016/S0921-8777(01)00085-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span>5-Formyluracil is a major oxidation product of </span>thymine, formed in DNA in yields comparable to that of 8-oxo-7,8-dihydroguanine by exposure to γ-irradiation. Whereas the repair pathways for removal and the biological effects of persisting 8-oxo-7,8-dihydroguanine are much elucidated, much less attention has been paid to the cellular implications of 5-formyluracil in DNA. Here we review the present state of knowledge in this important area within research on oxidative DNA damage.</p></div>\",\"PeriodicalId\":100935,\"journal\":{\"name\":\"Mutation Research/DNA Repair\",\"volume\":\"486 2\",\"pages\":\"Pages 147-154\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2001-07-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S0921-8777(01)00085-4\",\"citationCount\":\"29\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Mutation Research/DNA Repair\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0921877701000854\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Mutation Research/DNA Repair","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0921877701000854","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
5-Formyluracil is a major oxidation product of thymine, formed in DNA in yields comparable to that of 8-oxo-7,8-dihydroguanine by exposure to γ-irradiation. Whereas the repair pathways for removal and the biological effects of persisting 8-oxo-7,8-dihydroguanine are much elucidated, much less attention has been paid to the cellular implications of 5-formyluracil in DNA. Here we review the present state of knowledge in this important area within research on oxidative DNA damage.
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