枯草赖氨酸/克辛9型原蛋白转换酶抑制剂时代之前降脂治疗的历史里程碑

Pedro-Botet Juan, Elisenda Climent, David Benaiges
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引用次数: 1

摘要

有广泛而有力的证据表明低密度脂蛋白(LDL)胆固醇是动脉粥样硬化的一个原因。使用降脂药物来减少含载脂蛋白B(主要是ldl)的脂蛋白的致动脉粥样硬化负荷,可以减缓动脉粥样硬化疾病的进展,如果及早开始积极治疗,甚至可以逆转这种疾病。本文综述了用于心血管预防的各种降脂药物的发展历史,不包括蛋白转化酶枯草杆菌素/ keexin -9型(PCSK9)抑制剂,并总结了单个药物的主要前瞻性干预性临床试验的结果,以确定其降低ldl -胆固醇浓度的潜在心血管益处。
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Hitos históricos en el tratamiento hipolipemiante antes de la era de los inhibidores de la proproteina convertasa subtilisina/kexina tipo 9

There is extensive, strong evidence that low-density lipoprotein (LDL) cholesterol is a causal factor for atherosclerosis. The use of lipid-lowering drugs to reduce the atherogenic load of lipoproteins containing apolipoprotein B, mainly LDLs, slows the progression of atheromatous disease and could even reverse it if treatment is started early and aggressively. This review provides a historical perspective on the development of the various lipid-lowering drugs used for cardiovascular prevention, excluding proprotein convertase subtilisin/kexin type-9 (PCSK9) inhibitors, and summarizes the findings of the main prospective interventional clinical trials of individual agents in order to identify the potential cardiovascular benefits associated with their ability to reduce LDL-cholesterol concentrations.

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来源期刊
Revista Espanola de Cardiologia Suplementos
Revista Espanola de Cardiologia Suplementos Medicine-Cardiology and Cardiovascular Medicine
CiteScore
1.20
自引率
0.00%
发文量
1
期刊介绍: Revista Española de Cardiología, is an international scientific journal dealing with cardiovascular medicine. Revista Española de Cardiología, the official publication of the Spanish Society of Cardiology, publishes research articles related to cardiovascular diseases. Articles are published in Spanish for the paper edition and in both Spanish and English in the electronic edition, which is available on the Internet. Regular sections include original articles reporting clinical or basic research, brief reports, review articles, editorials and letters to the Editor.
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