小儿髓母细胞瘤和毛细胞星形细胞瘤的神经心理学比较:现有知识和未来方向

A. Holland
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引用次数: 7

摘要

本文综述了小儿髓母细胞瘤和小脑毛细胞星形细胞瘤的神经心理学晚期效应的现有知识,以突出未来的研究领域。这两种肿瘤占据大脑的同一区域,比较这两种肿瘤可以说是研究颅脊髓放射晚期效应的理想方法,因为髓母细胞瘤患者接受放射治疗,而小脑毛细胞星形细胞瘤患者不接受放射治疗。这种尚未广泛开展的比较研究,有可能加强有针对性的神经心理学干预,并帮助神经肿瘤学家做出有关放射使用、频率、持续时间和剂量的治疗决定。本文还讨论了认知流畅性,详细介绍了在这两个肿瘤组中研究这一被忽视的结构的重要性。这些人群的不同处理速度缺陷的现有知识似乎与颅脊髓放射治疗密切相关,为此类调查提供了理论依据。
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Neuropsychological Comparison of Pediatric Medulloblastoma and Pilocytic Astrocytoma: Existing Knowledge and Future Directions
This paper reviews existing knowledge regarding neuropsychological late effects of pediatric medulloblastoma and cerebellar pilocytic astrocytoma, with the goal of highlighting areas for future research. Comparison of these two tumors, which occupy the same region of the brain, is arguably the ideal method for researching the late effects of craniospinal radiation, as medulloblastoma patients receive radiation, while cerebellar pilocytic astrocytoma patients do not. Such comparative research, which has yet to be extensively conducted, has the potential to enhance targeted neuropsychological interventions and help neuro-oncologists make treatment decisions regarding use, frequency, duration, and dose of radiation. A discussion of cognitive fluency is included, detailing the importance of researching this overlooked construct in these two tumor groups. Existing knowledge of differential processing speed deficits in these populations, which appears to be strongly related to administration of craniospinal radiation, provides a rationale for such investigation.
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