{"title":"碳酸盐磷灰石中碳酸盐含量对骨置换的影响","authors":"Kaai Deguchi, Shunsuke Nomura, Akira Tsuchiya, Ichiro Takahashi, Kunio Ishikawa","doi":"10.1002/term.3270","DOIUrl":null,"url":null,"abstract":"<p>Carbonate apatite (CO<sub>3</sub>Ap), an inorganic component of human bone, has been clinically applied as an artificial bone substitute. In this study, the effects of the CO<sub>3</sub> content in CO<sub>3</sub>Ap on the replacement by new bone were studied by fabricating CO<sub>3</sub>Ap granules containing 0.9–8.3 wt% of CO<sub>3</sub>. The dissolution rate of CO<sub>3</sub>Ap in a weak acidic solution, mimicking the Howship's lacunae, was rapid for the CO<sub>3</sub>Ap granules containing a larger amount of CO<sub>3</sub>. Histological analyses demonstrated the rapid resorption in CO<sub>3</sub>Ap and replacement by natural bone tissue when the CO<sub>3</sub> content was increased. Therefore, the CO<sub>3</sub> content in CO<sub>3</sub>Ap is a key factor that influences the replacement of the bone tissue.</p>","PeriodicalId":202,"journal":{"name":"Journal of Tissue Engineering and Regenerative Medicine","volume":"16 2","pages":"200-206"},"PeriodicalIF":3.1000,"publicationDate":"2021-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"8","resultStr":"{\"title\":\"Effects of the carbonate content in carbonate apatite on bone replacement\",\"authors\":\"Kaai Deguchi, Shunsuke Nomura, Akira Tsuchiya, Ichiro Takahashi, Kunio Ishikawa\",\"doi\":\"10.1002/term.3270\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Carbonate apatite (CO<sub>3</sub>Ap), an inorganic component of human bone, has been clinically applied as an artificial bone substitute. In this study, the effects of the CO<sub>3</sub> content in CO<sub>3</sub>Ap on the replacement by new bone were studied by fabricating CO<sub>3</sub>Ap granules containing 0.9–8.3 wt% of CO<sub>3</sub>. The dissolution rate of CO<sub>3</sub>Ap in a weak acidic solution, mimicking the Howship's lacunae, was rapid for the CO<sub>3</sub>Ap granules containing a larger amount of CO<sub>3</sub>. Histological analyses demonstrated the rapid resorption in CO<sub>3</sub>Ap and replacement by natural bone tissue when the CO<sub>3</sub> content was increased. Therefore, the CO<sub>3</sub> content in CO<sub>3</sub>Ap is a key factor that influences the replacement of the bone tissue.</p>\",\"PeriodicalId\":202,\"journal\":{\"name\":\"Journal of Tissue Engineering and Regenerative Medicine\",\"volume\":\"16 2\",\"pages\":\"200-206\"},\"PeriodicalIF\":3.1000,\"publicationDate\":\"2021-11-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"8\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Tissue Engineering and Regenerative Medicine\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/term.3270\",\"RegionNum\":3,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOTECHNOLOGY & APPLIED MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Tissue Engineering and Regenerative Medicine","FirstCategoryId":"5","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/term.3270","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
Effects of the carbonate content in carbonate apatite on bone replacement
Carbonate apatite (CO3Ap), an inorganic component of human bone, has been clinically applied as an artificial bone substitute. In this study, the effects of the CO3 content in CO3Ap on the replacement by new bone were studied by fabricating CO3Ap granules containing 0.9–8.3 wt% of CO3. The dissolution rate of CO3Ap in a weak acidic solution, mimicking the Howship's lacunae, was rapid for the CO3Ap granules containing a larger amount of CO3. Histological analyses demonstrated the rapid resorption in CO3Ap and replacement by natural bone tissue when the CO3 content was increased. Therefore, the CO3 content in CO3Ap is a key factor that influences the replacement of the bone tissue.
期刊介绍:
Journal of Tissue Engineering and Regenerative Medicine publishes rapidly and rigorously peer-reviewed research papers, reviews, clinical case reports, perspectives, and short communications on topics relevant to the development of therapeutic approaches which combine stem or progenitor cells, biomaterials and scaffolds, growth factors and other bioactive agents, and their respective constructs. All papers should deal with research that has a direct or potential impact on the development of novel clinical approaches for the regeneration or repair of tissues and organs.
The journal is multidisciplinary, covering the combination of the principles of life sciences and engineering in efforts to advance medicine and clinical strategies. The journal focuses on the use of cells, materials, and biochemical/mechanical factors in the development of biological functional substitutes that restore, maintain, or improve tissue or organ function. The journal publishes research on any tissue or organ and covers all key aspects of the field, including the development of new biomaterials and processing of scaffolds; the use of different types of cells (mainly stem and progenitor cells) and their culture in specific bioreactors; studies in relevant animal models; and clinical trials in human patients performed under strict regulatory and ethical frameworks. Manuscripts describing the use of advanced methods for the characterization of engineered tissues are also of special interest to the journal readership.